Imacent 400 mg (Tablet)

Unit Price: ৳ 300.00 (5 x 6: ৳ 9,000.00)
Strip Price: ৳ 1,800.00

Medicine Details

Category Details
Generic Imatinib mesylate
Company Incepta pharmaceuticals ltd
Also available as

Indications

  • Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML) in chronic phase
  • Patients with Philadelphia chromosome positive chronic myeloid leukemia in blast crisis, accelerated phase, or in chronic phase after failure of interferon-alpha therapy
  • Adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL)
  • Pediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy
  • Adult patients with myelodysplastic/myeloproliferative diseases associated with platelet-derived growth factor receptor (PDGFR) gene re-arrangements
  • Adult patients with aggressive systemic mastocytosis without the D816V c-Kit mutation or with c-Kit mutational status unknown
  • Adult patients with hypereosinophilic syndrome and/or chronic eosinophilic leukemia who have the FIP1L1-PDGFR a fusion kinase
  • Adult patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans
  • Patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors
  • Adjuvant treatment of adult patients following complete gross resection of Kit (CD117) positive GIST

Pharmacology

  • Small molecule protein-tyrosine kinase inhibitor
  • Inhibits Bcr-Abl tyrosine kinase and several receptor tyrosine kinases
  • Absorption and Distribution details provided
  • Metabolism through CYP3A4 enzyme
  • Excretion in feces mostly as metabolites

Dosage & Administration

  • Adults with Ph+ CML CP: 400 mg/day
  • Pediatrics with Ph+ CML CP: 340 mg/m2/day
  • Adults with Ph+ ALL: 600 mg/day
  • Adults with ASM: 100 mg/day or 400 mg/day
  • Imatinib should be taken with a meal and a large glass of water

Interaction

  • Agents Inducing CYP3A Metabolism
  • Agents Inhibiting CYP3A Metabolism
  • Interactions with Drugs Metabolized by CYP3A4
  • Interactions with Drugs Metabolized by CYP2D6

Side Effects

  • Fluid Retention and Edema
  • Hematologic Toxicity
  • Congestive Heart Failure and Left Ventricular Dysfunction
  • Hepatotoxicity
  • Hemorrhage
  • Gastrointestinal Disorders
  • Hypothyroidism
  • Growth Retardation in Children and Adolescents
  • Tumor Lysis Syndrome
  • Impairments Related to Driving and Using Machinery
  • Renal Toxicity

Pregnancy & Lactation

  • Use of effective contraception advised for women of childbearing potential
  • Limited data on use in pregnant women
  • Advice against breastfeeding during treatment

Precautions & Warnings

  • Edema and severe fluid retention
  • Cytopenias
  • Severe congestive heart failure and left ventricular dysfunction
  • Severe hepatotoxicity
  • Grade 3/4 hemorrhage
  • Bullous dermatologic reactions
  • Hypothyroidism
  • Fetal harm
  • Growth retardation in children
  • Tumor Lysis Syndrome
  • Reports of motor vehicle accidents
  • Renal Toxicity

Overdose Effects

  • Limited experience with high doses
  • Reported effects of overdose in adults and pediatric population

Therapeutic Class

Targeted Cancer Therapy, Tyrosine Kinase Inhibitor

Storage Conditions

Store below 30°C, in a cool and dry place, Keep away from light

Related Brands