Prosan 25 mg (Tablet)
Unit Price: ৳ 4.50 (6 x 10: ৳ 270.00)
Strip Price: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50mg daily
- 25mg twice daily for inadequate antihypertensive effect
- Lower starting dose for patients over 75 years
- Total daily dose ranges from 25mg to 100mg
Interaction
- Rifampicin and fluconazole reduce active metabolite levels
- Concomitant use with hydrochlorothiazide for potentiation
- Concomitant use with potassium-sparing diuretics may lead to serum potassium increases
- Attenuation by non-steroidal anti-inflammatory drug indomethacin
- Increased risk of renal impairment with ACE-inhibitor, angiotensin receptor antagonist, and thiazide diuretic combination
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Not to be administered with aliskiren in diabetic patients
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased fetal risk if administered during second or third trimesters
- Potential excretion in human milk
- Nursing decision based on drug importance to the mother
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death during second and third trimesters
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose in patients with moderate to severe renal impairment or on dialysis
- Lower dose recommended for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children