Prosan 50 mg (Tablet)
Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Angiotensin-ll receptor blocker
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting dose of 50 mg once daily
- Maintenance dose of 50 mg once daily for most patients
- If inadequate, may increase to 25 mg twice daily
- Starting dose of 25 mg once daily for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce active metabolite levels
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes may increase serum potassium
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with the use of certain drugs
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to fetus if administered during second or third trimester
- Unknown excretion in human milk
- Consideration for discontinuation of nursing or drug
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death in second and third trimesters
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment for patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with hepatic impairment
- Caution in patients with intravascular volume depletion
- Caution in patients with history of hepatic impairment
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children