Proval 200 mg (Tablet)

Unit Price: ৳ 2.52 (5 x 10: ৳ 126.00)
Strip Price: ৳ 25.20

Medicine Details

Category Details
Generic Sodium valproate
Company General pharmaceuticals ltd
Also available as
Proval cr 200 mg tablet Proval 200 mg syrup Proval cr 300 mg tablet Proval cr 500 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet contains 200mg Sodium Valproate BP
  • Sodium Valproate syrup contains 200mg Sodium Valproate BP per 5ml
  • Sodium Valproate controlled release 200 tablets contain 200mg Sodium Valproate BP and 133.2mg Valproic acid BP
  • Sodium Valproate controlled release 300 tablets contain 300mg Sodium Valproate BP and 199.8mg Valproic acid BP
  • Sodium Valproate controlled release 500 tablets contain 500mg Sodium Valproate BP and 333mg Valproic acid BP
  • Sodium Valproate injection contains Sodium Valproate BP eql. to Valproic Acid 500mg per 5ml

Pharmacology

  • Mechanism of anti-epileptic activity
  • Increase in brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Different dosage for adults and children with epilepsy
  • Initial dosage and maximum dosage for epilepsy treatment
  • Dosage for prophylaxis of febrile convulsion
  • Dosage for bipolar disorder treatment
  • Dosage range for prophylaxis of migraine
  • Specific dosage recommendations for injection in adults and children

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Common side effects such as anorexia, nausea, and vomiting
  • Effects on the CNS including sedation, ataxia, and tremor
  • Occasional effects on liver function including elevation of liver enzymes in plasma
  • Adverse effects on children below 2 years and those being treated with multiple antiepileptic agents

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborn if exposed in the first trimester
  • Excretion in breast milk

Precautions & Warnings

  • Monitoring of liver functions
  • Ensuring no undue potential for bleeding before major surgery
  • Care in renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus
  • Potential false interpretation of urine ketone test
  • Avoiding sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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