RePACE 25 mg (Tablet)
Unit Price: ৳ 4.51 (5 x 10: ৳ 225.50)
Strip Price: ৳ 45.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Total daily dose ranges from 25 mg to 100 mg
- Different dosage adjustments for patients of different age groups
- Can be administered once or twice daily
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increase in serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Not to be administered with aliskiren in diabetes patients
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy category D
- Increased fetal risk if administered during second or third trimester
- Uncertain excretion in human milk, potential adverse effects on nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death in second and third trimesters
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significant increase in plasma concentration in cirrhotic patients
- Changes in renal function and renal failure in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children