Brinz T 1%+0.5% (Ophthalmic Suspension)

5 ml drop: ৳ 550.00

Medicine Details

Category	Details
Generic	Brinzolamide timolol
Company	Osl pharma limited

Decrease of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension for whom monotherapy provides insufficient IOP reduction.

Potent inhibitor of human carbonic anhydrase II (CA-II),
Non-selective beta-adrenergic blocking agent
Inhibition of CA-II in the ciliary processes of the eye decreases aqueous humour secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
Tonography and fluorophotometry studies in man suggest that its predominant action is related to reducing aqueous humour formation and a slight increase in outflow facility.

The recommended dosage is one drop in the conjunctival sac of the affected eye(s) twice daily.

A history of hypersensitivity to Brinzolamide and other Sulphonamides, Timolol, or any other component of the medication.

Pregnancy Category C.
No adequate data from the use of Brinzolamide in pregnant women.
Studies in animals have shown reproductive toxicity.
The potential risk for humans is unknown.
Data on a limited number of exposed pregnancies indicate no adverse effects of Timolol in eye drops on pregnancy or on the health of the foetus.
Bradycardia and arrhythmia have been reported in one case in the foetus of a woman treated with Timolol eye drops.
It is not known whether Brinzolamide is excreted in human breast milk.
Animal studies have shown excretion of Brinzolamide in breast milk.
Timolol does appear in human breast milk; however, at therapeutic doses of brinzolamide and Timolol ophthalmic suspension, no effects on the breastfed infants are anticipated.
Brinzolamide and Timolol ophthalmic suspension can be used during breastfeeding.

Acid-base disturbances have been reported with oral carbonic anhydrase inhibitors.
If signs of serious reactions or hypersensitivity occur, discontinue use of this medicine.
Due to the beta-adrenergic component, Timolol, the same types of cardiovascular and pulmonary adverse reactions as seen with systemic beta-adrenergic blocking agents may occur.
Cardiac failure should be adequately controlled before beginning therapy with Timolol.
Patients with a history of severe cardiac disease should be watched for signs of cardiac failure and have their pulse rates checked.

Do not store above 30°C temperature.
Keep away from light and wet place.
Keep out of reach of children.
To prevent contamination of the dropper tip and suspension, care should be taken, not to touch the eyelids, surrounding areas, finger or other surfaces with the dropper tip of the bottle.
The bottle should be tightly closed when not in use.
Do not use after 4 weeks of first opening.