Bakticef 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Osl pharma limited |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Kills bacteria by interfering with the synthesis of the bacterial cell wall. Long plasma elimination half-life of about 6 to 9 hours. Not metabolized in the body. Highly protein bound (95%).
Dosage
- Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day
- Infants and Children (01 month or older) usual dose is 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day
- Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections using Lidocaine HCI 1% or Water for injection
- Injection should be administered over specified durations or patient tolerance test should be checked by administration of a test dose
- Solution maintains potency for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
No drug interactions reported
Contraindications
Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis occurs rarely following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established. Caution should be exercised when administered to a lactating mother
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Shadows suggesting sludge have been detected by sonograms of the gallbladder
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment of overdosage should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30°C) away from light & moisture. Keep out of the reach of children