G-Ceftriax 2 gm/vial (IV Injection)

2 gm vial: ৳ 175.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Gonoshasthaya pharma ltd
Also available as
G ceftriax 250 mg injection G ceftriax 500 mg injection G ceftriax 1 gm injection G ceftriax 250 mg injection G ceftriax 500 mg injection G ceftriax 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms.

Dosage

  • Adult: The usual dose is 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Infants and Children (01 month or older): The usual dose is 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Preparation for Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Preparation for Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection
    • 1 g Ceftriaxone in 10 ml of Water for injection USP
    • 2 g Ceftriaxone in 20 ml of Water for injection

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects:
    • Diarrhea
    • Nausea and vomiting
    • Stomatitis
    • Glossitis
  • Cutaneous reactions:
    • Rash
    • Pruritus
    • Urticaria
    • Edema
    • Erythema multiforme
  • Hematologic reactions:
    • Eosinophilia
    • Thrombocytopenia
    • Leucopenia
    • Anemia
    • Neutropenia
  • Hepatic reactions:
    • Elevations of SGOT or SGPT
    • Bilirubinemia
  • CNS reactions:
    • Nervousness
    • Confusion
    • Sleep disturbances
    • Headache
    • Hyperactivity
    • Convulsion
    • Hypertonia
    • Dizziness
  • Local phlebitis: Occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Low concentrations of Ceftriaxone are excreted in human milk. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock: Requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
  • Gallbladder condition: Shadows suggesting sludge have been detected by sonograms of the gallbladder. This condition was reversible on discontinuation or completion of therapy. Conservative, nonsurgical management is recommended if such findings are associated with pain.
  • Blood picture: Should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.

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