Domfix 10 mg (Tablet)
Unit Price: ৳ 2.50 (10 x 10: ৳ 250.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Osl pharma limited |
| Also available as |
Title
- Domfix 10 mg Tablet
Categories
- Medicine
- Gastrointestinal Health
- Nausea & Vomiting Relief
- Parkinson's Disease Support
- Radiological Studies Aid
Description
- Domperidone is a dopamine antagonist medication
- Relieves dyspeptic symptom complex
- Treats acute nausea and vomiting
- Speeds barium transit in radiological studies
- Restores normal motility and tone of the upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis and lower esophageal sphincter pressure
Dimensions
- 10-20 mg tablet or 10-20 ml suspension
- 30-60 mg rectal suppositories
Color Options
- Not applicable
Functions
- Relieves dyspeptic symptoms
- Treats acute nausea and vomiting
- Speeds barium transit in radiological studies
Materials
- Domperidone
Technical Specifications
- Molecular Formula: C22H24ClN5O2
- Chemical Structure: [Link to image]
Design Elements
- Tablet form
- Suspension form
- Rectal suppositories
Usability Features
- Should be taken 15-30 minutes before meals
- Orally administered
- Rectally administered
Dosage
- 10-20 mg for adults every 6-8 hours daily
- 2-4 ml suspension/10 kg body weight for children every 6-8 hours daily
- 0.4-0.8 ml pediatric drops/10 kg body weight for children every 6-8 hours daily
Recommended Uses
- Adults: relief of dyspeptic symptoms and acute nausea/vomiting
- Children: relief of dyspeptic symptoms and acute nausea/vomiting
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiotherapy or drug-induced nausea/vomiting
- Radiological studies involving barium transit
Pharmacology
- Blocks dopamine receptors in Chemoreceptor Trigger Zone and stomach
- Gastroprokinetic action
- Restores normal motility and tone of upper gastrointestinal tract
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Enhances antral and duodenal peristalsis
Interaction
- Anticholinergic drugs may antagonize antidyspeptic effect
- Antacids and antisecretory drugs lower oral bioavailability
- Metabolized through CYP3A4 pathway
- Inhibition of CYP3A4 may increase plasma levels
- Potential influence on absorption of concomitantly administered drugs
- No influence on neuroleptics and dopaminergic agonists
Contraindications
- Known hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Perforation
- Prolactin releasing pituitary tumor
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Possible increase in plasma prolactin level
- Rare allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Use in first trimester if justified by therapeutic benefit
- Excreted in breast milk
- Concentrations in breast milk lower than plasma
- Effect on newborn unknown
Precautions & Warnings
- Absolute caution in the case of children
- Increased risk of extra-pyramidal reactions in young children
- Use with caution in hepatic impairment
Use in Special Populations
- Use with caution in infants
- Use with caution in liver disorders
- Use with caution in severe renal insufficiency
Overdose Effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Administration of activated charcoal recommended
Therapeutic Class
- Motility Stimulants
- Dopamine Antagonist
- Prokinetic Drugs
Storage Conditions
- Store below 30°C
- Protected from light and moisture