Tobracin D 0.1%+0.3% (Ophthalmic Ointment)

Indications

• Steroid responsive inflammatory ocular conditions
• Chronic anterior uveitis
• Corneal injury from chemical, radiation, or thermal burns
• Penetration of foreign bodies

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of protein synthesis
• Inhibition of phospholipase A2 by Dexamethasone
• Anti-inflammatory activity of Dexamethasone

Dosage & Administration

• Eye Drops administration
• Eye Ointment application
• Pediatric Use caution

Interaction

• No specific interaction studies performed
• Interval between successive applications

Contraindications

• Epithelial herpes simplex keratitis
• Mycobacterial infection of the eye
• Hypersensitivity to any component

Side Effects

• Hypersensitivity reactions
• Localized ocular toxicity
• Elevation of intraocular pressure
• Posterior subcapsular cataract formation
• Delayed wound healing

Pregnancy & Lactation

• Use during pregnancy with caution
• Systemic absorption in human milk
• Potent risk to the fetus

Precautions & Warnings

• Possibility of fungal infections of the cornea
• Prolonged use leading to overgrowth of non-susceptible organisms
• Cross-sensitivity to other aminoglycoside antibiotics

Overdose Effects

• Overdose through local administration not known
• Accidental oral intake precautions

Therapeutic Class

• Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

• Store at room temperature
• Close bottle immediately after use
• Do not use for longer than one month after opening

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