Xelotan 50 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Pharmasia limited |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- 25 mg once daily for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
- No initial dosage adjustment for patients upto 75 years
Interaction
- Rifampicin and fluconazole reduce active metabolite levels
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase serum potassium levels
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component of the product
- Not to be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to the fetus in the second or third trimesters
- Potential excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal impaired patients
- Dosage adjustment needed in patients with mild to severe renal impairment or on dialysis
- A lower dose should be considered for patients with a history of hepatic impairment
- Use with caution in patients with bilateral renal artery stenosis or a solitary kidney
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
- Lower dose consideration for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children