Sefin 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 80.55

Medicine Details

Category Details
Generic Cephradine
Company Orion pharma ltd
Also available as
Sefin 250 mg capsule Sefin 500 mg capsule Sefin 125 mg suspension Sefin ds 250 mg suspension Sefin 125 mg pediatric drop Sefin 250 mg injection Sefin 500 mg injection

Title

  • Sefin Antibiotic Medicine

Categories

  • Pharmaceuticals
  • Medicine
  • Healthcare

Description

  • Broad spectrum bactericidal antibiotic
  • Effective against Gram-positive and Gram-negative bacteria
  • Semi-synthetic
  • Suitable for oral and injectable administration
  • Indicated for upper respiratory tract infections
  • Indicated for lower respiratory tract infections
  • Indicated for urinary tract infections
  • Indicated for skin and soft tissue infections
  • Interacts with nephrotoxic drugs
  • Contraindicated in patients with cephalosporin hypersensitivity
  • Excreted in breast milk
  • Precautions for cross-sensitivity with penicillins
  • Dosage adjustment in renal impairment

Dosage & Administration

  • Recommended dosage for adults with urinary tract infections
  • Recommended dosage for adults with respiratory tract infections
  • Recommended dosage for adults with skin and soft tissue infections
  • Dosage for children with otitis media
  • Maximum daily dosage for children
  • Dosage for elderly
  • Usual dosage for injectable administration in adults
  • Dosage for injectable administration in children

Pharmacology

  • Broad spectrum bactericidal action
  • Inhibition of bacterial cell wall synthesis
  • Inhibition of cross-linking process in peptidoglycan
  • Lysis of bacteria due to external osmotic pressure

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Occasional skin reactions
  • Rare effects like glossitis, dizziness, nausea, vomiting
  • Rare blood and lymphatic system disorders
  • Rare immune system disorders
  • Rare psychiatric disorders
  • Rare nervous system disorders
  • Rare hepatobiliary disorders
  • Rare renal and urinary disorders
  • Rare elevation in blood urea nitrogen and serum creatinine

Pregnancy & Lactation

  • No established safety in pregnancy
  • Excretion in breast milk
  • Caution in lactating mothers
  • Caution for patients operating hazardous machinery

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Cross-sensitivity with penicillins
  • Positive result in Coombs’ testing in neonates
  • Risk of false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Not suitable for patients with certain hereditary problems

Use in Special Populations

  • Recommended doses for renal impairment
  • Additional information for all patients
  • Caution in use for persistent infections
  • Transfer from intramuscular/intravenous to oral treatment

Overdose Effects

  • Non-specific symptoms of overdose
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepare suspension
  • Use reconstituted suspension within specified days
  • Use injection solutions within specified hours
  • Storage temperature impact on potency
  • Dispense only on prescription of a registered physician

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