Tone 100 mg (Tablet)
Unit Price: ৳ 0.73 (10 x 10: ৳ 73.00)
Strip Price: ৳ 7.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Thiamine hydrochloride |
| Company | Orion pharma ltd |
Indications
- Treatment of thiamine deficiency manifestations
- Beriberi treatment
- Wernick's encephalopathy treatment
- Neuritis treatment associated with pregnancy
- Pellagra treatment
- Prophylactic use in low dietary intake
- Prophylactic use in impaired gastrointestinal absorption of thiamine
- Prophylactic use in pregnancy
- Prophylactic use in carbohydrate rich diet
Pharmacology
- Thiamine pyrophosphate as coenzyme for decarboxylation
- Affects peripheral nervous system
- Affects gastrointestinal tract
- Affects cardiovascular system
- Necessary for optimal growth of infants and children
- Not stored in the body
- Regularly lost from tissues during deficiency
- Necessary amount required daily
- Deficiency leads to fatigue, anorexia, gastrointestinal disturbance, tachycardia, irritability, and neurological symptoms
- Well absorbed from gastrointestinal tract
- Rapid absorption from upper small intestine
- Not stored in the body to any appreciable extent
- Excess ingested thiamine appears in urine
- Plasma half-life of thiamine is 24 hours
Dosage & Administration
- Prophylaxis: 3 to 10 mg daily
- Mild chronic deficiency: 10 to 25 mg daily
- Severe deficiency: 200 to 300 mg daily
Interaction
- Acts synergistically with other B-complex group vitamins
- Reduced potential for causing adverse effects
Contraindications
- No absolute contraindications
- Increased risk of anaphylaxis with repeated parenteral administration
- Mild allergic phenomena as warning signs
- Avoid intravenous administration except in comatose patients
- No need for parenteral administration once deficiency is corrected
Side Effects
- No adverse effects when given orally
- Anaphylactic reactions in sensitive patients after intravenous administration of large doses
- Risk of reactions increases with repeated parenteral administration
- Transient soreness at the site of intramuscular administration
Pregnancy & Lactation
- Safe for neonates, children, pregnant, lactating women, and elderly patients
Therapeutic Class
- Vitamin-B preparations
Storage Conditions
- Protect from light and moisture