Abetis 10 mg (Tablet)
Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olmesartan medoxomil |
| Company | Aci limited |
| Also available as |
Indications
- Treatment of hypertension
- Can be used alone or in combination with other antihypertensive agents
Pharmacology
- Formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme
- Principal pressor agent of the renin-angiotensin system
- Selective blocking of the binding of angiotensin II to the AT 1 receptor in vascular smooth muscle
- More than 12,500-fold greater affinity for the AT 1 receptor than for the AT 2 receptor
- Does not inhibit ACE (kininase II), does not affect the response to bradykinin
- Inhibits the negative regulatory feedback of angiotensin II on renin secretion
Dosage & Administration
- Usual recommended starting dose of 20 mg once daily as monotherapy
- For patients requiring further reduction in blood pressure, the dose may be increased to 40 mg
- No initial dosage adjustment recommended for elderly patients
- Consideration should be given to use of a lower starting dose for patients with possible depletion of intravascular volume
- May be administered with or without food
- Safety and effectiveness in pediatric patients have not been established
Interaction
- No significant drug interactions with digoxin or warfarin
- Bioavailability not significantly altered by the co-administration of antacids
- Not metabolized by the cytochrome P450 system and has no effects on P450 enzymes
- Co-administration with NSAIDs including selective COX-2 inhibitors may result in deterioration of renal function
- Antihypertensive effect may be attenuated by NSAIDs including selective COX-2 inhibitors
Contraindications
- Hypersensitivity to any component of this product
Side Effects
- Well tolerated with an incidence of adverse reactions similar to placebo
- Overall frequency of adverse reactions not dose related
- Rate of withdrawals due to adverse reactions was low
- Most common adverse reaction was dizziness
- Other adverse reactions include back pain, bronchitis, diarrhea, headache, hyperglycemia, pharyngitis, and sinusitis
Pregnancy & Lactation
- Discontinue the product when pregnancy is detected
- Can cause injury and even death to the developing fetus when used during the second and third trimesters
- Potential for adverse effects on the nursing infant
Precautions & Warnings
- Changes in renal function may be anticipated in susceptible individuals
- Treatment has been associated with oliguria, progressive azotemia, acute renal failure, and death in some patients
Overdose Effects
- No experience of overdose with the product
- Most likely effects of overdosage are hypotension and tachycardia
- Clinically significant hypotension requires active support of the cardiovascular system
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Store in cool & dry place below 30°C
- Protect from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C29H30N6O6
- Chemical Structure: Image displaying the chemical structure
Common Questions about Abetis 10 mg Tablet
- Used to treat high blood pressure
- Average time taken to reach peak effect is around 1 day to 1 week
- Generally used once or twice a day
- Advised to be consumed orally
- Should be stored at room temperature, away from heat and direct light
Quick Tips
- Take the tablet at the same time every day
- Rise slowly if feeling dizzy in the initial days of usage
- Regular tests are recommended to monitor the level of urea, creatinine, and potassium in the blood
- Avoid taking anti-inflammatory medicines without consulting a doctor
- May increase the level of potassium in the blood, avoid potassium supplements and potassium-rich foods
- Do not take if pregnant or breastfeeding
- Do not stop taking suddenly without consulting the doctor