Farlan 50 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Triazole antifungal agent, inhibitor of fungal cytochrome P-450 dependent enzymes, responsible for the synthesis of ergosterol
Dosage & Administration
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
- 200 mg daily for Prevention of cryptococcal meningitis
- 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
Interaction
- Increases prothrombin time after warfarin administration
- Prolongs serum half-life of concomitantly administered oral sulphonyl ureas
- Increases plasma concentrations of hydrochlorothiazide
- Increases the level of phenytoin
- Results in a 25% decrease in the AUC and 20% shorter half-life of rifampicin
- Affects the AUCs of ethinyl estradiol and levonorgestrel
- Slowly increases cyclosporin concentrations
- No clinically significant impairment of absorption with food, cimetidine, antacids or following total body irradiation for bone marrow transplantation
Contraindications
Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash
- Rare anaphylaxis
Pregnancy & Lactation
Adverse fetal effects observed in animals at dose levels associated with maternal toxicity
Precautions & Warnings
- Observation of abnormalities in hepatic, renal, haematological and other biochemical function tests
- Rare development of exfoliative cutaneous reactions
- Not recommended for use during lactation
Use in Special Populations
- Normal dose should be used in the elderly if there is no evidence of renal impairment
- Excreted predominantly in urine, no adjustments in single dose therapy required, dosage intervals or daily dosage should be modified based on creatinine clearance
Overdose Effects
Supportive measures and symptomatic treatment with gastric lavage if necessary, forced volume diuresis may increase elimination rate, haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children