Linatin M 2.5 mg+850 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Adjunct to diet and exercise
- Improves glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Inhibitor of DPP-4 enzyme
- Increases active incretin hormones
- Stimulates insulin release
- Decreases glucagon secretion
- Biguanide type oral antihyperglycemic drug
- Lowers plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Dose escalation should be gradual
- Immediate release and extended release tablet options
- Recommended starting dose for different patient groups
Interaction
- Cationic drug interactions
- Carbonic anhydrase inhibitor interactions
- Inducers of P-glycoprotein and CYP3A4 enzyme interactions
- Drugs affecting glycemic control interactions
Contraindications
- Contraindicated in renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Nasopharyngitis
- Diarrhea
- Hypoglycemia
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Caution during lactation
Precautions & Warnings
- Discontinue in case of lactic acidosis or pancreatitis
- Temporary discontinuation for radiologic studies or surgical procedures
- Monitoring of Vitamin B12 levels
- Symptoms and precautions related to lactic acidosis
- General precautions for alcohol, other medicines, counseling, travel, emergency, and hypoglycemia
Overdose Effects
- Supportive measures for overdose
- Hemodialysis or peritoneal dialysis unlikely for Linagliptin
- Dialyzable characteristic of Metformin Hydrochloride
- No dose-related clinical adverse drug reactions for Linagliptin
- Hypoglycemia and lactic acidosis implications for Metformin Hydrochloride overdose
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children