Linatin M 2.5 mg+850 mg (Tablet)

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Delta pharma ltd
Also available as
Linatin m 25 mg tablet Linatin m 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control in adults with type 2 diabetes mellitus

Pharmacology

  • Inhibitor of DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon secretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage
  • Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
  • Dose escalation should be gradual
  • Immediate release and extended release tablet options
  • Recommended starting dose for different patient groups

Interaction

  • Cationic drug interactions
  • Carbonic anhydrase inhibitor interactions
  • Inducers of P-glycoprotein and CYP3A4 enzyme interactions
  • Drugs affecting glycemic control interactions

Contraindications

  • Contraindicated in renal impairment
  • Contraindicated in acute or chronic metabolic acidosis
  • Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride

Side Effects

  • Nasopharyngitis
  • Diarrhea
  • Hypoglycemia

Pregnancy & Lactation

  • Use during pregnancy only if clearly needed
  • Caution during lactation

Precautions & Warnings

  • Discontinue in case of lactic acidosis or pancreatitis
  • Temporary discontinuation for radiologic studies or surgical procedures
  • Monitoring of Vitamin B12 levels
  • Symptoms and precautions related to lactic acidosis
  • General precautions for alcohol, other medicines, counseling, travel, emergency, and hypoglycemia

Overdose Effects

  • Supportive measures for overdose
  • Hemodialysis or peritoneal dialysis unlikely for Linagliptin
  • Dialyzable characteristic of Metformin Hydrochloride
  • No dose-related clinical adverse drug reactions for Linagliptin
  • Hypoglycemia and lactic acidosis implications for Metformin Hydrochloride overdose

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store in a cool & dry place (below 30°C)
  • Protected from light & moisture
  • Keep out of the reach of children

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