Linatin M 2.5 mg+1000 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Delta pharma ltd
Also available as
Linatin m 25 mg tablet Linatin m 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control in adults with type 2 diabetes mellitus

Pharmacology

  • Inhibitor of DPP-4 enzyme
  • Stimulates insulin release
  • Decreases glucagon secretion
  • Lowers basal and postprandial plasma glucose
  • Improves insulin sensitivity

Dosage and Administration

  • Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Individualized dosage based on effectiveness and tolerability

Interaction

  • Potential interaction with cationic drugs
  • Caution with carbonic anhydrase inhibitors
  • Interactions with drugs affecting glycemic control
  • Effect of inducers on Linagliptin exposure

Contraindications

  • Contraindicated in renal impairment
  • Contraindicated in metabolic acidosis
  • Contraindicated in hypersensitivity

Side Effects

  • Most common: nasopharyngitis and diarrhea
  • Higher occurrence of hypoglycemia with sulfonylureas

Pregnancy and Lactation

  • Use during pregnancy only if clearly needed
  • Caution during lactation

Precautions and Warnings

  • Discontinue in case of lactic acidosis
  • Temporary discontinuation for radiologic studies or surgical procedures
  • Caution with Vitamin B12 levels
  • Symptoms and precautions for lactic acidosis
  • Guidance on alcohol, other medicines, counseling, travel, and emergency preparedness
  • Caution for hypoglycemia

Overdose Effects

  • Supportive measures in case of overdose
  • Hypoglycemia reported in approximately 10% of cases
  • Lactic acidosis reported in approximately 32% of cases

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Keep in a cool & dry place below 30°C
  • Protected from light & moisture
  • Keep out of reach of children

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