Linatin M 2.5 mg+1000 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Adjunct to diet and exercise
- Improves glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Inhibitor of DPP-4 enzyme
- Stimulates insulin release
- Decreases glucagon secretion
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
Dosage and Administration
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Individualized dosage based on effectiveness and tolerability
Interaction
- Potential interaction with cationic drugs
- Caution with carbonic anhydrase inhibitors
- Interactions with drugs affecting glycemic control
- Effect of inducers on Linagliptin exposure
Contraindications
- Contraindicated in renal impairment
- Contraindicated in metabolic acidosis
- Contraindicated in hypersensitivity
Side Effects
- Most common: nasopharyngitis and diarrhea
- Higher occurrence of hypoglycemia with sulfonylureas
Pregnancy and Lactation
- Use during pregnancy only if clearly needed
- Caution during lactation
Precautions and Warnings
- Discontinue in case of lactic acidosis
- Temporary discontinuation for radiologic studies or surgical procedures
- Caution with Vitamin B12 levels
- Symptoms and precautions for lactic acidosis
- Guidance on alcohol, other medicines, counseling, travel, and emergency preparedness
- Caution for hypoglycemia
Overdose Effects
- Supportive measures in case of overdose
- Hypoglycemia reported in approximately 10% of cases
- Lactic acidosis reported in approximately 32% of cases
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Keep in a cool & dry place below 30°C
- Protected from light & moisture
- Keep out of reach of children