Olmecar 20 mg (Tablet)

Title

• Olmecar 20 mg Tablet

Categories

• Medicine
• Antihypertensive
• Pharmacology

Description

• Olmecar is an angiotensin II receptor blocker used for the treatment of hypertension.
• It can be used alone or in combination with other antihypertensive agents.
• It blocks the binding of angiotensin II to the AT 1 receptor in vascular smooth muscle.
• The usual recommended starting dose is 20 mg once daily, which may be increased to 40 mg if necessary.
• It is generally well tolerated with an overall frequency of adverse reactions similar to placebo.
• It is contraindicated in patients who are hypersensitive to any component of the product.
• Discontinue the product if pregnancy is detected as it can cause injury to the developing fetus.

Dosage & Administration

• Individualized dosage
• Starting dose of 20 mg once daily
• Further reduction of blood pressure may require an increased dose to 40 mg
• Twice-daily dosing offers no advantage over once daily dosing
• No initial dosage adjustment recommended for elderly patients or those with moderate to marked renal impairment or hepatic dysfunction
• Consideration of lower starting dose for patients with possible depletion of intravascular volume
• May be administered with or without food

Interaction

• No significant drug interactions reported with digoxin or warfarin
• Bioavailability not significantly altered by co-administration of antacids
• Not metabolized by the cytochrome P450 system, and has no effects on P450 enzymes
• Co-administration with NSAIDs may result in deterioration of renal function
• Attenuation of the antihypertensive effect by NSAIDs including selective COX-2 inhibitors

Indications

• Treatment of hypertension
• May be used alone or in combination with other antihypertensive agents

Pharmacology

• Blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in vascular smooth muscle
• Does not inhibit ACE (kininase II) or affect the response to bradykinin
• Inhibits the negative regulatory feedback of angiotensin II on renin secretion

Contraindications

• Hypersensitivity to any component of the product

Side Effects

• Well tolerated with an incidence of adverse reactions similar to placebo
• Rate of withdrawals due to adverse reactions was low
• Dizziness was the most common adverse reaction
• Other adverse reactions occurred at similar or greater incidence in patients receiving placebo

Pregnancy & Lactation

• Discontinue the product when pregnancy is detected
• Can cause injury and even death to the developing fetus during the second and third trimesters
• Potential for adverse effects on the nursing infant

Precautions & Warnings

• Changes in renal function may be anticipated
• Treatment associated with oliguria, progressive azotemia, acute renal failure, and death in susceptible individuals

Overdose Effects

• No experience of overdose reported
• Likely effects include hypotension and tachycardia
• Clinically significant hypotension requires active support of the cardiovascular system

Therapeutic Class

• Angiotensin-ll receptor blocker

Storage Conditions

• Store in a cool & dry place below 30°C
• Protect from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C29H30N6O6

Common Questions

• Uses of Olmecar 20 mg Tablet include treating high blood pressure
• Average time for peak effect is around 1 day to 1 week
• Generally used once or twice a day
• Advised to be consumed orally and may cause dizziness initially
• Storage at room temperature, away from heat, and direct light
• Quick tips for taking the medication and precautions to be followed

Related Brands

• Abetis 40 mg (Tablet) - aci-limited
• Abetis 20 mg (Tablet) - aci-limited
• Abetis 10 mg (Tablet) - aci-limited