Ondamax 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Somatec pharmaceuticals ltd |
| Also available as |
Title
- Ondamax Oral Soluble Film
Categories
- Anti-emetic drugs
Description
- Orally dissolving film
- Serotonin subtype 3 (5-HT3) receptor antagonist
- Active ingredient: Ondamax base (racemic form of Ondamax)
- Empirical formula: C18H19N3O
- Molecular weight: 293.3
- Designed to dissolve on the tongue within 20 seconds
- Does not require water for dissolution or swallowing
Indications
- Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Mode of action not fully known
- Blocks vomiting reflex by antagonizing 5HT3 receptors
- May act on neurons in both peripheral and central nervous system
Dosage
- Various dosage options based on the type of nausea and vomiting
- Different dosing guidelines for adults, pediatric patients, and geriatric patients
Administration
- Instructions for using the Oral Soluble Film
- Step-by-step guide for administration
Interaction
- Metabolism by hepatic cytochrome P-450 drug-metabolizing enzymes
- Potential interaction with drugs that induce or inhibit these enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Common: headache, constipation, diarrhea
- Occasional: rash, sensation of flushing or warmth, hiccups, liver enzyme abnormalities
- Rare but severe: anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- No evidence of carcinogenic effects in animal studies
- No mutagenicity observed
- Caution in use during pregnancy and lactation due to excretion in breast milk
Precautions & Warnings
- Reported hypersensitivity reactions in some patients
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used as a substitute for nasogastric suction
Use in Special Populations
- Dosage recommendations for patients with impaired renal function
- Dosage adjustments for patients with impaired hepatic function
- Limited information on dosage for pediatric patients 4 years of age or younger
- No dosage adjustment needed for patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Keep in a dry place
- Protect from light and moisture