Rabeprol 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.90 (6 x 10: ৳ 414.00)
Strip Price: ৳ 69.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Somatec pharmaceuticals ltd
Also available as
Rabeprol 20 mg tablet Rabeprol 10 mg capsule

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Symptomatic treatment of erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal reflux disease long-term management (GERD maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in patients with peptic ulcer disease

Mode of Action

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • 20 mg dosage for active duodenal ulcer and active benign gastric ulcer
  • 20 mg dosage for erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily
  • 10 mg dosage for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • 5 mg dosage for pediatric patients 1 to 11 years of age (Less than 15 kg)
  • 10 mg dosage for pediatric patients 1 to 11 years of age (15 kg or more)
  • Starting dose of 60 mg once daily for Zollinger-Ellison Syndrome
  • Combination therapy for H. pylori eradication: rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, amoxicillin 1g twice daily

Administration

  • Rabeprazole tablets to be taken in the morning, before eating
  • Not to be chewed or crushed, but swallowed whole

Interaction

  • Possible interaction with compound absorption that is pH dependent
  • Co-administration with ketoconazole or itraconazole may reduce antifungal plasma levels
  • No interaction with liquid antacids
  • Atazanavir absorption is pH-dependent, should not be co-administered with PPIs

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • Potential excretion in human milk
  • No adequate and well-controlled studies in pregnant women

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric or esophageal malignancy
  • Long-term treatment may modestly increase the risk of hip, wrist and spine fracture
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitors
  • Blood dyscrasias and hepatic enzyme abnormalities observed
  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children

Overdose Effects

  • Maximum established exposure has not exceeded 60 mg twice daily, or 160 mg once daily
  • Generally minimal effects, reversible without further medical intervention
  • No specific antidote known
  • Treatment should be symptomatic

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions

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