Rabeprol 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 6.90 (6 x 10: ৳ 414.00)
Strip Price: ৳ 69.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rabeprazole sodium |
| Company | Somatec pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Treatment of active benign gastric ulcer
- Symptomatic treatment of erosive or ulcerative gastro-esophageal reflux disease (GERD)
- Gastro-esophageal reflux disease long-term management (GERD maintenance)
- Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
- Treatment of Zollinger-Ellison Syndrome
- Eradication of Helicobacter pylori in patients with peptic ulcer disease
Mode of Action
- Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase
- Characterized as a gastric proton-pump inhibitor
Dosage
- 20 mg dosage for active duodenal ulcer and active benign gastric ulcer
- 20 mg dosage for erosive or ulcerative gastro-esophageal reflux disease (GERD)
- Maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily
- 10 mg dosage for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
- 5 mg dosage for pediatric patients 1 to 11 years of age (Less than 15 kg)
- 10 mg dosage for pediatric patients 1 to 11 years of age (15 kg or more)
- Starting dose of 60 mg once daily for Zollinger-Ellison Syndrome
- Combination therapy for H. pylori eradication: rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, amoxicillin 1g twice daily
Administration
- Rabeprazole tablets to be taken in the morning, before eating
- Not to be chewed or crushed, but swallowed whole
Interaction
- Possible interaction with compound absorption that is pH dependent
- Co-administration with ketoconazole or itraconazole may reduce antifungal plasma levels
- No interaction with liquid antacids
- Atazanavir absorption is pH-dependent, should not be co-administered with PPIs
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Contra-indicated in pregnancy and during breastfeeding
Side Effects
- May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, dizziness
Pregnancy & Lactation
- US FDA pregnancy category 'C'
- Potential excretion in human milk
- No adequate and well-controlled studies in pregnant women
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric or esophageal malignancy
- Long-term treatment may modestly increase the risk of hip, wrist and spine fracture
- Risk of cross-hypersensitivity reactions with other proton pump inhibitors
- Blood dyscrasias and hepatic enzyme abnormalities observed
- No dosage adjustment necessary for patients with renal or hepatic impairment
- Not recommended for use in children
Use in Special Populations
- No dosage adjustment necessary for patients with renal or hepatic impairment
- Not recommended for use in children
Overdose Effects
- Maximum established exposure has not exceeded 60 mg twice daily, or 160 mg once daily
- Generally minimal effects, reversible without further medical intervention
- No specific antidote known
- Treatment should be symptomatic
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep below 30°C temperature, away from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C18H21N3O3S
Common Questions
- What is Rabeprol 20 mg Capsule?
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