Antif DS 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 65.20

Medicine Details

Category Details
Generic Amoxicillin trihydrate
Company Rangs pharmaceuticals ltd
Also available as
Antif 250 mg capsule Antif 500 mg capsule Antif 125 mg suspension Antif 125 mg pediatric drop

Indications

  • Ear, nose and throat infections
  • Lower respiratory tract infections
  • Skin and soft tissue infections
  • Genito-urinary tract infections
  • Venereal disease
  • Dental abscess therapy

Pharmacology

Effective against a wide range of Gram-positive and Gram-negative bacteria. Acts through the inhibition of biosynthesis of cell wall. Stable in the presence of gastric acid and rapidly absorbed after oral administration.

Dosage

  • Adult:
    • 250 mg three times daily
    • 500 mg three times daily for severe infections
  • Children:
    • 125 mg three times daily
    • 250 mg three times daily for severe infections
  • Severe or recurrent purulent respiratory infection: 3 gm every 12 hours
  • Otitis media:
    • 1 g three times daily for adults
    • 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily)
  • Pneumonia: 500-1000 mg three times daily
  • Dental abscess: 3 gm, repeated after 10-12 hours
  • Urinary tract infections: 3 gm, repeated after 10-12 hours
  • Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm

Administration

Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, or water.

Interaction

  • Concurrent use with Probenecid may result in increased and prolonged blood levels
  • May affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives

Contraindications

Contraindicated in penicillin hypersensitive patients.

Side Effects

  • Diarrhoea
  • Indigestion
  • Rash
  • Pseudo-membranous colitis (rarely reported)

Pregnancy & Lactation

  • FDA pregnancy category: B
  • Excreted in human milk: Caution should be exercised when administered to a lactating mother

Precautions & Warnings

The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy.

Therapeutic Class

Broad spectrum penicillins

Reconstitution

  • Amoxycillin 500 mg Injection:
    • Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial
    • Intravenous: Dissolve in 10 ml water for injection

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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