Antipro 200 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 29.89

Medicine Details

Category Details
Generic Metronidazole
Company Rangs pharmaceuticals ltd
Also available as
Antipro 400 mg tablet

Title

Antipro 200 mg/5 ml Suspension

Categories

  • Antibiotics
  • Antiprotozoal Agents
  • Amoebicides

Description

Antipro is indicated for the prevention of post-operative infections due to anaerobic bacteria, treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, urogenital trichomoniasis, bacterial vaginosis, all forms of amoebiasis, giardiasis, acute ulcerative gingivitis, anaerobically infected leg ulcers, pressure sores, acute dental infections, antibiotic-associated pseudomembranous colitis, and more. It belongs to the imidazole class of antibacterial drugs and is classified therapeutically as an antiprotozoal agent. The drug interacts with DNA and provides bactericidal action.

Dimensions

N/A

Color options

  • N/A

Functions

  • Prevention of infections
  • Treatment of various bacterial and parasitic infections

Materials

  • Metronidazole (active ingredient)
  • Excipients

Technical specifications

  • Tablet and Suspension:
    • Adult Dosage:
      • 200 mg tid or 400 mg bid for 7 days
      • 800 mg in the morning and 1-2 gm at night for 2 days
      • 2 gm as a single dose for 1 day
    • Children Dosage:
      • 100 mg tid for children 7-10 yrs
      • 100 mg bid for children 3-7 yrs
      • 50 mg tid for children 1-3 yrs
  • Vaginal Gel: Recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days
  • Suppository:
    • Anaerobic Infections:
      • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
      • Children: 500 mg every 8 hours for 3 days, then every 12 hours (5-10 years), Over 10 years adult dose
    • Surgical Prophylaxis:
      • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high-risk procedures
      • Children: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high-risk procedures (5-10 years)
  • IV Infusion:
    • Adults and Children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute, maximum of 4 g should not be exceeded during a 24-hour period
    • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute

Design elements

  • Suspension
  • Tablet
  • Vaginal Gel
  • Suppository
  • IV Infusion

Usability features

  • Suitable for adults and children
  • Treatment and prophylaxis for various bacterial and parasitic infections

Indications

  • Post-operative infections due to anaerobic bacteria
  • Septicaemia
  • Bacteraemia
  • Peritonitis
  • Brain abscess
  • Pelvic abscess
  • Pelvic cellulitis
  • Urogenital trichomoniasis
  • Bacterial vaginosis
  • All forms of amoebiasis
  • Giardiasis
  • Acute ulcerative gingivitis
  • Anaerobically infected leg ulcers
  • Pressure sores
  • Acute dental infections
  • Antibiotic associated pseudomembranous colitis

Interaction

  • Disulfiram: Psychotic reactions reported when used concurrently with Antipro
  • Alcohol: Should not be consumed during therapy and for at least one day afterwards due to the possibility of a disulfiram-like reaction
  • Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk
  • Lithium: Plasma levels may be increased by Antipro
  • Cyclosporin: Serum levels should be closely monitored when co-administered
  • Phenytoin or phenobarbital: Increased elimination of Antipro resulting in reduced plasma levels
  • 5-Fluorouracil: Reduced clearance resulting in increased toxicity
  • Busulfan: Plasma levels may be increased by Antipro, leading to severe toxicity

Contraindications

  • History of hypersensitivity to Metronidazole or other Nitroimidazole derivatives

Side effects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

Pregnancy and lactation

  • Pregnancy: Category B; should be used during pregnancy only if clearly needed
  • Lactation: Caution should be exercised when administered to a nursing woman, as it is excreted in human milk

Precautions and warnings

  • Regular hematological tests recommended
  • Monitor for adverse reactions such as peripheral or central neuropathy
  • Administer with caution to patients with hepatic encephalopathy

Special populations

  • Hepatic Impairment: Administered with caution; daily dosage should be reduced to one third and may be administered once daily
  • Renal Impairment: No reduction in dosage needed; metabolites retained, clinical significance not known

Overdose effects

Symptomatic and supportive treatment should be instituted in case of suspected massive overdosages

Therapeutic class

  • Amoebicides
  • Anti-diarrhoeal
  • Antiprotozoal

Storage conditions

Store below 30°C, protected from light, out of the reach of children, and not beyond the expiry date

Common questions

  • What is Antipro 200 mg/5 ml Suspension?
  • What are the uses of Antipro 200 mg/5 ml Suspension?
  • What are the side effects of Antipro 200 mg/5 ml Suspension?
  • How long do I need to use Antipro 200 mg/5 ml Suspension before I see improvement of my conditions?
  • What are the contraindications to Antipro 200 mg/5 ml Suspension?
  • Is Antipro 200 mg/5 ml Suspension safe to use when pregnant?
  • Will Antipro 200 mg/5 ml Suspension be more effective if taken in more than the recommended dose?
  • Quick Tips: Including treatment information and precautions

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