Lindex 1 gm/vial (IM/IV Injection)

Indications

• Treatment of upper respiratory tract infections
• Treatment of lower respiratory tract infections
• Treatment of urinary tract infections
• Treatment of skin and soft tissue infections
• Susceptible microorganisms (gram-positive)
• Susceptible microorganisms (gram-negative)

Pharmacology

• Broad spectrum bactericidal antibiotic
• Active against gram-positive and gram-negative microorganisms
• Inhibition of cross-linking process in cell wall of bacteria
• Formation of cell wall pores leading to bacterial cell lysis

Dosage & Administration

• Recommended dosage for adults with urinary tract infections
• Recommended dosage for adults with respiratory tract infections
• Recommended dosage for adults with skin and soft tissue infections
• Total daily dose for children with otitis media
• Maximum daily dosage for children

Interaction

• Increased risk of kidney damage with nephrotoxic drugs
• Enhanced renal toxicity with diuretics and probenecid

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

• Gastrointestinal disturbances
• Hypersensitivity phenomena
• Occasional skin reactions
• Rare side effects e.g. glossitis, dizziness, nausea, vomiting
• Blood and lymphatic system disorders
• Immune system disorders
• Psychiatric disorders
• Nervous system disorders
• Hepatobiliary disorders
• Renal and urinary disorders
• Elevation of certain blood and serum parameters

Pregnancy & Lactation

• Absence of teratogenicity in animal studies
• Excretion of medication in breast milk
• Caution in lactating mothers

Precautions & Warnings

• Potential for superinfection with prolonged use
• Cross-sensitivity with penicillins
• Potential for false positive urine glucose result
• Dosage adjustment in renal impairment
• Contains lactose, caution in patients with specific intolerances

Use in Special Populations

• Recommended doses for patients with renal impairment
• Additional information for all patients
• Limitation on pediatric dosages
• Requirement for bacteriological and clinical monitoring

Overdose Effects

• Non-specific symptoms (nausea, vomiting, diarrhoea)
• Supportive treatment
• Possible need for gastric lavage

Therapeutic Class

• First generation cephalosporins

Storage Conditions

• Shelf life of reconstituted suspension (room temperature and refrigerated)
• Shelf life of injection solutions (room temperature and refrigerated)
• Variation in color of reconstituted solutions
• Dispensation only on prescription of a registered physician

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