Losartium 50 mg (Tablet)
Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Rangs pharmaceuticals ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily for most patients
- 25 mg twice daily recommended if 50 mg once daily is inadequate
- 25 mg once daily starting dose for patients with intravascular volume-depletion
- Lower starting dose of 25 mg once daily recommended for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use of hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium
- Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concurrent use with Aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Upper respiratory infection
- Fatigue
- Edema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus in second or third trimester
- Not known whether excreted in human milk
Precautions & Warnings
- Reduction of fetal renal function and increased fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or patients on dialysis
- Use in patients with intravascular volume depletion
- Use in hepatic impairment
- Contra-indications and warnings related to pregnancy and hypersensitivity
Therapeutic Class
Angiotensin-II receptor blocker
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.