Losartium-H 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Rangs pharmaceuticals ltd

Indications

  • Treatment of hypertension
  • Reducing risk of stroke in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Blockage of vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Selective binding of angiotensin II to the AT<sub>1 </sub>receptor
  • Potent vasoconstrictor and primary vasoactive hormone
  • Stimulation of aldosterone secretion
  • Thiazide diuretic effect on renal tubular mechanisms

Dosage

  • Usual starting dose of 50/12.5: one tablet once daily
  • Antihypertensive effect attained within three weeks
  • No initial dosage adjustment necessary for elderly patients

Administration

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Interaction

  • No significant drug-drug pharmacokinetic interactions found in interaction studies
  • Increased serum potassium with concomitant use of potassium-sparing diuretics
  • Potential interaction with non-steroidal anti-inflammatory drug Indomethacin
  • Possible interaction with alcohol, barbiturates, narcotics
  • Possible dosage adjustment of antidiabetic drugs
  • Additive effect or potentiation with other antihypertensive drugs

Contraindications

  • Hypersensitivity to any component of the product
  • Anuria or hypersensitivity to other sulfonamide-derived drugs

Side Effects

  • Mild side effects such as symptomatic hypotension, dizziness, hyperkalaemia, angioedema
  • Vertigo, gastro-intestinal disturbances, angina, palpitation, oedema, dyspnoea, headache, sleep disorders
  • Malaise, urticaria, pruritus, rash, hepatitis, atrial fibrillation, cerebrovascular accident, syncope
  • Pancreatitis, anaphylaxis, cough, depression, erectile dysfunction, anaemia, thrombocytopenia
  • Hyponatraemia, arthralgia, myalgia, renal impairment, rhabdomyolysis, tinnitus, photosensitivity, vasculitis

Pregnancy & Lactation

  • Avoid in pregnancy unless essential
  • Adverse effects on fetal and neonatal blood pressure control and renal function
  • Not recommended in breastfeeding

Precautions & Warnings

  • Periodic determination of serum electrolytes
  • Risk of hypokalemia especially with brisk diuresis or severe cirrhosis
  • Risk of impaired renal function and symptomatic hypotension

Use in Special Populations

  • Usual regimens of therapy may be followed with creatinine clearance >30 ml/min
  • Loop diuretics preferred in more severe renal impairment
  • Not recommended in patients with hepatic impairment
  • Safety and effectiveness not established in pediatric patients

Overdose Effects

  • Manifestations of overdosage may include hypotension, tachycardia, bradycardia
  • Supportive treatment for symptomatic hypotension
  • No removal by hemodialysis

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Do not store above 30°C

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