Oryx 2 gm/vial (IV Injection)
2 gm vial: ৳ 351.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Rangs pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- 3rd generation broad-spectrum parenteral cephalosporin antibiotic
- Bactericidal activity against Gram-positive and Gram-negative organisms
- Interferes with bacterial cell wall synthesis
- High stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Highly protein bound (95%)
Dosage
- Adult dosage: 1 to 2 gm intravenously or intramuscularly once a day
- Maximum adult dose: 4 gm/day
- Infants and Children dosage: 50 to 75 mg/kg intravenously or intramuscularly once a day
- Maximum pediatric dose: 2 gm/day
- Duration of therapy: 4 to 14 days
Administration
- Preparation of solutions for intramuscular/ intravenous injections
- Administered over 2-4 minutes intramuscularly or intravenously
- Freshly reconstituted solution recommended
- Room temperature stability of 6 hours or 24 hours at 5°C
Interaction
- No reported drug interactions
Contraindications
- Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects like diarrhea, nausea, vomiting
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions like eosinophilia, thrombocytopenia
- Hepatic reactions such as elevations of SGOT or SGPT
- CNS reactions like nervousness, confusion
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety not established in human pregnancy
- Caution advised during lactation
Precautions & Warnings
- Risk of anaphylactic shock
- Monitor blood picture during prolonged treatment
Use in Special Populations
- Not recommended for premature and newborn neonates
Overdose Effects
- No specific antidote, treat symptomatically
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store vial below 30°C, away from light & moisture