Orafen Plus (75 mg+20 mg)/2 ml (IM Injection)

2 ml ampoule: ৳ 15.05 (10's pack: ৳ 150.50)

Medicine Details

Category Details
Generic Diclofenac sodium lidocaine hydrochloride
Company Rangs pharmaceuticals ltd

Indications

  • Relief of pain and inflammation
  • Arthritic conditions such as rheumatoid arthritis, osteoarthritis, juvenile chronic arthritis, ankylosing spondylitis, acute gout
  • Acute musculoskeletal disorders such as periarthritis (e.g., Frozen shoulder), tendinitis, tenosynovitis, bursitis
  • Pain resulting from trauma including fracture, low back pain, sprains, strains, dislocations
  • Control of pain and inflammation in orthopaedic, dental and other minor surgeries
  • Postoperative pain
  • Pain of renal colic
  • Local anaesthetic action due to Lidocaine

Pharmacology

  • Potent nonsteroidal antiinflammatory drug (NSAID)
  • Marked analgesic and antipyretic properties
  • Uricosuric effects
  • Inhibition of prostaglandin synthesis
  • Inhibition of cyclooxygenase
  • Rapid onset and stability of Lidocaine
  • Impairs generation and conduction of nerve impulses

Dosage & Administration

  • Adult dosage: one ampoule once daily by intramuscular injection
  • Renal colic dosage: one ampoule intramuscularly, may administer a second dose if necessary
  • Children dosage for juvenile chronic arthritis
  • Recommended lowest effective dosage for elderly patients

Interaction

  • Potential interactions with Lithium, Digoxin, anticoagulants, antidiabetic agents, Cyclosporin, Methotrexate, quinolone antimicrobials, other NSAIDs, steroids, and diuretics

Contraindications

  • Hypersensitivity to Diclofenac
  • Active or suspected peptic ulcer or gastrointestinal bleeding
  • Hypersensitivity to local anaesthetics of the amide type
  • Adams-Stokes syndrome
  • Severe degrees of heart block
  • Hypersensitivity to excipients used in the formulation

Side Effects

  • Gastrointestinal discomfort
  • Nausea
  • Diarrhea
  • Bleeding
  • Injection site disorder
  • Abscesses
  • Local necrosis
  • Central nervous system (CNS) reactions: drowsiness, dizziness, disorientation, confusion, lightheadedness

Pregnancy & Lactation

  • Not recommended during pregnancy unless compelling reasons
  • Lowest effective dosage should be used
  • Not recommended during the last trimester of pregnancy
  • Small quantities may be detected in breast milk

Precautions & Warnings

  • Close observation for patients with severe hepatic, cardiac, or renal insufficiency
  • Monitoring of renal function for patients using NSAIDs
  • Discontinuation if abnormal liver function tests persist or worsen
  • Monitoring for patients under long term NSAID treatment

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Store in a dry place
  • Protected from light

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