Pregaran 75 mg (Capsule)

Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Pregabalin
Company Rangs pharmaceuticals ltd
Also available as
Pregaran 25 mg capsule Pregaran 50 mg capsule

Indications

  • Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
  • Postherpetic neuralgia (PHN)
  • Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
  • Fibromyalgia
  • Neuropathic pain associated with spinal cord injury

Therapeutic Class

  • Adjunct anti-epileptic drugs
  • Primary anti-epileptic drugs

Pharmacology

Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It does not bind directly to GABA receptors but binds with high affinity to the alpha2-delta site in central nervous system tissues.

Dosage

  • Adult Dosage for DPN: 50-100 mg three times a day; maximum 300 mg/day
  • Adult Dosage for PHN: 75-150 mg two times a day or 50-100 mg three times a day; maximum 300 mg two times a day or 200 mg three times a day
  • Adult Dosage for Fibromyalgia: 300-450 mg/day
  • Adult Dosage for Spinal Cord Injury: 150-600 mg/day

Administration

  • Route of Administration: Oral
  • Pregabalin CR Tablet Administration: Swallow whole after an evening meal

Drug interaction with medication

Pregaran is unlikely to be involved in significant pharmacokinetic drug interactions.

Contraindications

Hypersensitivity to Pregabalin or any of its components

Side Effects

  • Common Adult Side Effects:
    • Dizziness
    • Somnolence
    • Dry mouth
    • Edema
    • Blurred vision
    • Weight gain
    • Difficulty with concentration/attention
  • Common Pediatric Side Effects:
    • Increased weight
    • Increased appetite

Pregnancy & Lactation

  • Pregnancy: No adequate and well-controlled studies, potential risk to fetus
  • Lactation: Small amounts detected in the milk of lactating women, not recommended during treatment

Precautions & Warnings

  • Angioedema can occur and may be associated with life threatening respiratory compromise
  • Discontinue immediately in case of hypersensitivity reactions
  • Increase risk of suicidal thoughts or behavior
  • May cause dizziness, somnolence, and impair ability to drive or operate machinery
  • Withdraw gradually over a minimum of 1 week
  • May cause peripheral edema

Use in Special Populations

  • Pediatric Use: Not established for various conditions and age groups
  • Pregaran extended-release tablet use in pediatric patients: Not established

Overdose Effects

  • Signs & Symptoms:
    • Reduced consciousness
    • Depression/anxiety
    • Confusional state
    • Agitation
    • Restlessness
    • Seizures
    • Heart block
  • Treatment: No specific antidote, general supportive care indicated

Storage Conditions

Keep in a cool & dry place (below 30°C), protected from light & moisture

Chemical Structure

  • Molecular Formula: C8H17NO2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg

Common Questions

  • What is Pregaran 75 mg Capsule?: Anticonvulsant, first-line treatment for neurotic pain, shingles, seizures, and fibromyalgia
  • How long do I need to use Pregaran 75 mg Capsule before I see improvement?: Till improvement is seen
  • At what frequency do I need to use Pregaran 75 mg Capsule?: As prescribed by the doctor
  • Should I use Pregaran 75 mg Capsule empty stomach, before food or after food?: After food in prescribed dosage
  • Instructions for storage and disposal of Pregaran 75 mg Capsule: Keep in cool dry place, in original packaging, and out of reach of children and pets
  • Does Pregaran 75 mg Capsule work in the same way for each disease?: No, it works differently for different diseases
  • How long do I need to take Pregaran 75 mg Capsule?: Depends on the condition; consult the doctor
  • Is it necessary to continue taking Pregaran 75 mg Capsule even if I feel fine?: Yes, consult the doctor before stopping
  • Can I take Diazepam and Pregaran 75 mg Capsule together?: Yes, they can be used together
  • Can the use of Pregaran 75 mg Capsule cause weight gain?: May cause weight gain due to increased hunger; consult a dietician if concerned

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