Opezen 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 4: ৳ 140.00)
Strip Price: ৳ 28.00

Medicine Details

Category Details
Generic Omeprazole
Company Zenith pharmaceuticals ltd
Also available as
Opezen 20 mg tablet

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Substituted benzimidazole
  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg for benign gastric and duodenal ulcer
  • 40 mg for severe or recurrent cases
  • 8 weeks for gastric ulceration
  • 10-20 mg daily for acid-related dyspepsia
  • 40 mg for prophylaxis of acid aspiration
  • 60 mg for Zollinger-Ellison syndrome
  • Omeprazole is recommended at a dose of 20 mg twice daily for Helicobacter pylori eradication regimen

Administration

  • Omeprazole IV injection to be given slowly over a period of 5 minutes
  • Omeprazole IV infusion over a period of 20-30 minutes or more
  • Reconstituted solution should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations increased during concomitant administration with clarithromycin

Contraindications

  • Known hypersensitivity

Side Effects

  • Skin rash
  • Urticaria
  • Photosensitivity
  • Diarrhoea
  • Headache
  • Constipation
  • Nausea/vomiting
  • Dry mouth
  • Dizziness
  • Somnolence
  • Insomnia
  • Reversible mental confusion
  • Arthritic and myalgic symptoms

Pregnancy & Lactation

  • No adverse effects on pregnancy or the health of the fetus/newborn child

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Opezen
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis in long-term treatment

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat

Related Brands