Rampril 5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ramipril |
| Company | Rangs pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Congestive heart failure
- Acute myocardial infarction
- Glomerular or incipient nephropathy
- Reduction in the risk of myocardial infarction
- Stroke
- Cardiovascular death
- Manifest coronary heart disease
- History of stroke
- Peripheral vascular disease
- Diabetes mellitus
Pharmacology
- Angiotensin converting enzyme (ACE) inhibitor
- Vasoconstrictor substance inhibition
- Decreased plasma angiotensin II
- Decreased vasopressor activity
- Decreased aldosterone secretion
- Antihypertensive activity
- Management of heart failure
- Risk reduction for stroke, myocardial infarction, and cardiovascular events
Dosage
- Adjustable according to patient tolerance and response
- Usual initial dose of 1.25-2.5 mg once daily for hypertension
- Initial dose of 2.5 mg twice daily for heart failure after myocardial infarction
- Recommended dose of 2.5 mg once daily for preventing major cardiovascular events
- Specific dosages for renal impairment
Administration
- Tablets must be swallowed with liquid
- Must not be chewed or crushed
- Absorption not significantly affected by food
- Can be taken before, during, or after a meal
Interaction
- Concomitant administration with diuretics may lead to serious hypotension and hyperkalemia
- Concomitant therapy with lithium may increase serum lithium concentration
- Reduction in BP may affect ability to drive and operate machinery
- Interaction with NSAIDs
Contraindications
- Hypersensitivity to ramipril or any other ACE inhibitor
- History of angioedema
- Concomitant use with sacubitril/valsartan therapy
- Haemodynamically relevant renal artery stenosis
- Hypotensive or haemodynamically unstable states
- Concomitant use with aliskiren-containing medicines in patients with diabetes or moderate to severe renal impairment
- Concomitant use with angiotensin II receptor antagonists (AIIRAs) in patients with diabetic nephropathy
- During pregnancy
Side effects
- Dizziness
- Headache
- Fatigue
- Symptomatic hypotension
- Cough
- Nausea
- Vomiting
- Diarrhoea
- Rash
- Urticaria
- Oliguria
- Anxiety
- Amnesia
- Angioneurotic oedema
- Anaphylactic reactions
- Hyperkalemia
Pregnancy lactation
- Must not be taken during pregnancy
- Pregnancy must be excluded before starting treatment
- Pregnancy must be avoided if treatment with ACE inhibitors is indispensable
- Not recommended during breastfeeding
Precautions warnings
- Caution in patients with impaired renal function, hyperkalaemia, hypotension, and impaired hepatic function
Special populations
- Reduced initial dose for elderly patients
- Initiation under close medical supervision for patients with hepatic impairment
- Dosing considerations for patients with renal impairment
- Consideration for patients pretreated with a diuretic
Overdose effects
- Excessive peripheral vasodilatation
- Marked hypotension
- Shock
- Bradycardia
- Electrolyte disturbances
- Renal failure
Therapeutic class
- Angiotensin-converting enzyme (ACE) inhibitors
Storage conditions
- Store at 30° or below
- Protect from light
- Keep out of the reach of children
- Do not use later than the date of expiry
- To be dispensed only on the prescription of a registered physician