Vesodil 6.25 mg (Tablet)

Unit Price: ৳ 3.01 (3 x 10: ৳ 90.30)
Strip Price: ৳ 30.10

Medicine Details

Indications

  • Treatment of mild heart failure
  • Treatment of moderate heart failure
  • Treatment of severe heart failure
  • Treatment of heart failure of ischemic origin
  • Treatment of heart failure of cardiomyopathic origin
  • Reduction of progression of heart failure
  • Reduction of cardiovascular death
  • Reduction of cardiovascular hospitalization
  • Adjunct to digitalis
  • Adjunct to diuretics
  • Adjunct to ACE inhibitor
  • Usage in patients unable to tolerate ACE inhibitor
  • Usage in patients not receiving digitalis
  • Usage in patients not receiving hydralazine or nitrate therapy

Pharmacology

  • Non-selective antagonism of β-adrenergic receptors
  • α-adrenergic antagonistic activity
  • Antiproliferative properties
  • Scavenger of reactive free oxidant radicals
  • Treatment of hypertension
  • Treatment of angina pectoris
  • Treatment of congestive heart failure

Dosage & Administration

  • Initial dosage for hypertension: 12.5 mg once daily
  • Usual dosage for hypertension: 25 mg once daily
  • Maximum dosage for hypertension: 50 mg daily
  • Initial dosage for angina pectoris: 12.5 mg twice daily
  • Usual dosage for angina pectoris: 25 mg twice daily
  • Maximum dosage for angina pectoris: 50 mg daily
  • Initial dosage for heart failure: 3.125 mg twice daily
  • Incremental dosage for heart failure at 2-week intervals
  • Maximum dosage for heart failure

Interaction

  • Interaction with Digoxin
  • Interaction with Rifampin
  • Interaction with Warfarin
  • Interaction with Clonidine

Contraindications

  • Decompensated heart failure
  • Bronchial asthma
  • Bronchospastic conditions
  • Second or third-degree AV block
  • Sick sinus syndrome
  • Cardiogenic shock
  • Severe bradycardia

Side Effects

  • Postural hypotension
  • Dizziness
  • Headache
  • Fatigue
  • Gastro-intestinal disturbances
  • Bradycardia
  • Peripheral circulation issues
  • Peripheral oedema
  • Painful extremities
  • Dry mouth
  • Dry eyes
  • Eye irritation
  • Disturbed vision
  • Impotence
  • Micturition disturbances
  • Influenza-like symptoms
  • Angina
  • AV block
  • Exacerbation of claudication
  • Exacerbation of Raynaud's phenomenon
  • Allergic skin reactions
  • Exacerbation of psoriasis
  • Nasal stuffiness
  • Wheezing
  • Depressed mood
  • Sleep disturbances
  • Paresthesia
  • Heart failure
  • Liver enzyme changes
  • Thrombocytopenia
  • Leukopenia

Pregnancy & Lactation

  • Not for use during breast-feeding
  • Studies not performed in lactating women
  • Excretion in breast milk
  • Safety and efficacy not established in children
  • Not for use during pregnancy
  • Excretion across placental barrier
  • Safety and efficacy not established in neonates

Precautions & Warnings

  • Caution in hepatic impairment
  • Monitoring after initiation
  • Monitoring after increasing each dose
  • Monitoring renal function
  • Monitoring heart failure status

Therapeutic Class

  • Alpha adrenoceptor blocking drugs
  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C
  • Away from light
  • Away from moisture
  • Keep out of the reach of children

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