Vesodil 6.25 mg (Tablet)
Unit Price: ৳ 3.01 (3 x 10: ৳ 90.30)
Strip Price: ৳ 30.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Rangs pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild heart failure
- Treatment of moderate heart failure
- Treatment of severe heart failure
- Treatment of heart failure of ischemic origin
- Treatment of heart failure of cardiomyopathic origin
- Reduction of progression of heart failure
- Reduction of cardiovascular death
- Reduction of cardiovascular hospitalization
- Adjunct to digitalis
- Adjunct to diuretics
- Adjunct to ACE inhibitor
- Usage in patients unable to tolerate ACE inhibitor
- Usage in patients not receiving digitalis
- Usage in patients not receiving hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension
- Treatment of angina pectoris
- Treatment of congestive heart failure
Dosage & Administration
- Initial dosage for hypertension: 12.5 mg once daily
- Usual dosage for hypertension: 25 mg once daily
- Maximum dosage for hypertension: 50 mg daily
- Initial dosage for angina pectoris: 12.5 mg twice daily
- Usual dosage for angina pectoris: 25 mg twice daily
- Maximum dosage for angina pectoris: 50 mg daily
- Initial dosage for heart failure: 3.125 mg twice daily
- Incremental dosage for heart failure at 2-week intervals
- Maximum dosage for heart failure
Interaction
- Interaction with Digoxin
- Interaction with Rifampin
- Interaction with Warfarin
- Interaction with Clonidine
Contraindications
- Decompensated heart failure
- Bronchial asthma
- Bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral circulation issues
- Peripheral oedema
- Painful extremities
- Dry mouth
- Dry eyes
- Eye irritation
- Disturbed vision
- Impotence
- Micturition disturbances
- Influenza-like symptoms
- Angina
- AV block
- Exacerbation of claudication
- Exacerbation of Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Heart failure
- Liver enzyme changes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not for use during breast-feeding
- Studies not performed in lactating women
- Excretion in breast milk
- Safety and efficacy not established in children
- Not for use during pregnancy
- Excretion across placental barrier
- Safety and efficacy not established in neonates
Precautions & Warnings
- Caution in hepatic impairment
- Monitoring after initiation
- Monitoring after increasing each dose
- Monitoring renal function
- Monitoring heart failure status
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C
- Away from light
- Away from moisture
- Keep out of the reach of children