Vesodil 12.5 mg (Tablet)
Unit Price: ৳ 5.02 (3 x 10: ৳ 150.60)
Strip Price: ৳ 50.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Rangs pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate, or severe heart failure
- Treatment in conjunction with digitalis, diuretics, and ACE inhibitor
- Reduction in the progression of disease
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose in hypertension: 12.5 mg once daily
- Usual dose in hypertension: 25 mg once daily
- Dose in heart failure: 3.125 mg to 25 mg twice daily
- Dose in angina pectoris: 12.5 mg to 25 mg twice daily
- Dose adjustment based on patient's body-weight
Interaction
- Interaction with digoxin
- Interaction with rifampin
- Interaction with warfarin
- Interaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock or severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Exacerbation of psoriasis
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not to be used during breastfeeding
- No established safety and efficacy in children
- Not to be used during pregnancy
- Crosses placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitoring clinical status in heart failure
- Monitoring renal function
- Monitoring deterioration in heart failure
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children