Losa 25 mg (Tablet)
Unit Price: ৳ 3.51 (3 x 10: ৳ 105.30)
Strip Price: ৳ 35.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Alco pharma ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor
- Reduces vasoconstriction and the release of aldosterone
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Dosage range from 25 mg to 100 mg daily
- Different dosage recommendations for patients under 75 years and over 75 years
Interaction
- Reduction of active metabolite levels by Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Possible increase in serum potassium with potassium-sparing diuretics or supplements
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component of the product
- Not to be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects may include fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to fetus when administered during second or third trimesters
- Unknown excretion in human milk, potential adverse effects on nursing infant
Precautions & Warnings
- Reduction of fetal renal function during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- Different dosage adjustments for patients with renal impairment
- Use with caution in patients with hepatic impairment
- Contraindications and warnings related to use with other antihypertensive agents, intravascular volume depletion, and hepatic impairment
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children