Metmin 500 mg (Tablet)

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Alco pharma ltd
Also available as
Metmin 850 mg tablet Metmin xr 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Used in overweight patients
  • Reduction of diabetic complications
  • First-line therapy after diet failure

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosage increases in increments
  • Different doses for adults and children
  • Usual starting dose for immediate and extended release tablet
  • Dosage adjustments for renal impaired patients

Interaction

  • No chronic interaction with Furosemide
  • Interaction with Nifedipine
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes risk during pregnancy
  • Recommendation to use insulin during pregnancy
  • Metformin excretion in breast milk
  • No adverse effects observed in breastfed newborns

Precautions & Warnings

  • Risk of Metmin accumulation and lactic acidosis with impaired renal function
  • Potential lower vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function
  • Discontinuation before surgery
  • Advised against use in dehydrated or infected patients
  • Regular monitoring of Vitamin B-12 levels
  • Hypoglycemia risk with sulphonylurea combination

Use in Special Populations

  • Elderly dosage adjustment based on renal function
  • No effect on growth and puberty detected in controlled clinical studies
  • Caution in prescribing to children aged 10-12 years
  • Creatinine clearance determination before treatment
  • Decreased renal function in elderly
  • Special caution in situations altering renal function
  • Contradictions with GFR<30 ml/min

Overdose Effects

  • Hypoglycemia not seen with Metmin doses up to 85gm
  • Lactic acidosis seen in high doses
  • Hemodialysis for lactate and Metmin removal

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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