Infecef 500 mg/vial (IM Injection)

500 mg vial: ৳ 150.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Alco pharma ltd
Also available as
Infecef 250 mg injection Infecef 1 gm injection Infecef 1 gm injection Infecef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a relatively long plasma elimination half-life of about 6 to 9 hours and is not metabolized in the body. It is highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day

Administration

  • Preparation for Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in Water for injection
  • Preparation for Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Water for injection
    • 1 g Ceftriaxone in Water for injection USP
    • 2 g Ceftriaxone in Water for injection

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness

Pregnancy & Lactation

Safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Infecef must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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