Infecef 1 gm/vial (IV Injection)

1 gm vial: ৳ 220.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Alco pharma ltd
Also available as
Infecef 250 mg injection Infecef 500 mg injection Infecef 1 gm injection Infecef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacological Action

3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms.

Half-Life

6 to 9 hours

Metabolism

Not metabolized in the body

Excretion

40-65% in urine, remainder in bile and feces

Protein Binding

95%

Dosage Adult

  • Usual Dose: 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day
  • Maximum Dose: 4 gm/day
  • Specific Doses:
    • Pneumonia, Bronchitis, Acute bacterial otitis media, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections, Meningitis: 1 to 2 g IV or IM once a day or in equally divided doses twice a day
    • Uncomplicated gonococcal infections: 250 mg IM as a single dose
    • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery

Dosage Infants Children

  • Usual Dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day
  • Maximum Dose: 2 gm/day
  • Specific Doses:
    • Pneumonia, Bronchitis, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections: 50 to 75 mg/kg IV or IM once a day or in equally divided doses twice a day
    • Acute bacterial otitis media: 50 mg/kg IM in single dose
    • Meningitis: 100 mg/kg IV or IM in single daily dose or in equally divided doses twice a day

Duration of Therapy

More than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required

Administration

  • Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone in Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone in Water for injection
    • 1 g Ceftriaxone in 10 ml of Water for injection USP
    • 2 g Ceftriaxone in 20 ml of Water for injection
  • Administration Time: 2-4 minutes for injection, 30 minutes for tubing infusion
  • Patient Tolerance Test: Recommended before starting treatment
  • Solution Stability: Potency maintained for at least 6 hours at room temperature or 24 hours at 5°C

Drug Interactions

No drug interactions reported

Contraindications

Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Common:
    • Diarrhea
    • Nausea and vomiting
    • Stomatitis and glossitis
    • Rash
    • Pruritus
    • Urticaria
    • Edema
    • Erythema multiforme
  • Less Common:
    • Eosinophilia
    • Thrombocytopenia
    • Leucopenia
    • Anemia
    • Neutropenia
    • Elevations of SGOT or SGPT
    • Bilirubinemia
    • CNS reactions (nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, dizziness)
    • Local phlebitis (rare following intravenous administration)

Pregnancy Lactation

  • Pregnancy Use: Not established unless absolutely indicated
  • Lactation Use: Caution advised

Precautions Warnings

  • Anaphylactic shock potential
  • Gallbladder sonogram findings (reversible on discontinuation or completion of therapy)
  • Blood picture monitoring during prolonged treatment

Pediatric Use

Avoid in neonates if premature or newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Symptomatic treatment recommended

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture, and out of reach of children

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