Tolec 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.17

Medicine Details

Indications

  • Short-term management of post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • May be used to decrease eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Mainly metabolized in the liver
  • Metabolites and some unchanged drugs excreted in the urine

Pharmacology

  • Potent analgesic
  • Inhibits cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection: Administer as single or multiple doses for moderately severe, acute pain
  • Onset of analgesic effect: Within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM
  • Duration of analgesic effect: 4 to 6 hours

Interaction

  • Interaction with other NSAIDs or aspirin: Increase side effects
  • Interaction with anti-coagulants: Enhance anti-coagulant effect
  • Interaction with Beta Blocker: Reduce anti-hypertensive effect
  • Interaction with ACE Inhibitors: Increase risk of renal impairment
  • Interaction with Methotrexate: Enhance toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

Avoid during pregnancy and lactation unless potential benefits to the mother outweigh possible risks to the fetus

Precautions & Warnings

  • Exercise caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding
  • Caution in patients with asthma and liver dysfunction
  • For eye drops: Discontinue use if evidence of corneal epithelial breakdown, avoid use with contact lenses

Therapeutic Class

  • Rheumatoid Arthritis medication
  • Non-Opioid Analgesics

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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