Saver 400 mg (Capsule)
Unit Price: ৳ 50.15 (2 x 4: ৳ 401.20)
Strip Price: ৳ 200.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefixime trihydrate |
| Company | Alco pharma ltd |
| Also available as |
Title
- Saver 400 mg Capsule
Categories
- Antibiotic
- Medication
Description
- An orally active cephalosporin antibiotic with bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms.
Dosage
- The usual course of treatment is 7 days, may be continued for up to 14 days if required.
Mode of Action
- Bactericidal against a broad spectrum of gram-positive and gram-negative bacteria by interfering in the synthesis of bacterial cell wall.
Indications
- Treatment of upper respiratory tract infections (URTI), lower respiratory tract infections, urinary tract infections caused by susceptible microorganisms.
Contraindications
- Known hypersensitivity to cephalosporin antibiotics.
Storage Conditions
- Keep below 30°C temperature, protected from light & moisture, out of the reach of children.
Therapeutic Class
- Third generation Cephalosporins
Pregnancy & Lactation
- Use during pregnancy only if clearly needed, caution when administered to a nursing woman.
Precautions & Warnings
- Given with caution to patients who have shown hypersensitivity to other drugs, administered with caution in patients with markedly impaired renal function.
Interaction
- Increases in prothrombin times noted, care should be taken in patients receiving anticoagulant therapy.
Side Effects
- Gastrointestinal disturbances, central nervous system effects, hypersensitivity reactions, hematological and clinical chemistry changes.
Overdose Effects
- Gastric lavage may be indicated, no specific antidote exists, not removed in significant quantities by hemodialysis or peritoneal dialysis.
Compound Summary
- Molecular Formula: C16H15N5O7S2, Chemical Structure available
Commonly Asked Questions
- About uses, side effects, storage, treatment of cold and flu, special dietary instructions, use in infants, classification, interactions, usage with acetaminophen, time to work, when to inform a doctor, and quick tips.
Hypersensitivity Reactions
- Rash, pruritus, urticaria, drug fever, arthralgia.
Usual Adult Dosage
- 200-400 mg daily according to the severity of the infection, given either as a single dose or in two divided doses.
Elderly Dosage
- Same dose as recommended for adults, renal function assessment and dosage adjustment in severe renal impairment.
Children's Dosage
- 8 mg/kg/day administered as a single dose or in two divided doses, specific daily doses suggested based on age and weight.
Dosage in Renal Impairment
- Administered in the presence of impaired renal function, dose and schedule adjustment based on creatinine clearance.
Digestive System Effects
- Diarrhea, stool changes, nausea, abdominal pain, dyspepsia, vomiting, flatulence, and pseudomembranous colitis.
Neurological Effects
- Headache and dizziness.
Hematological and Clinical Chemistry Effects
- Thrombocytopenia, leukopenia, eosinophilia, mild transient change in liver and renal function tests.
Miscellaneous Effects
- Genital pruritus, vaginitis.
Effects on Breastfeeding
- Cautious usage during nursing.
Dietary Instructions
- Continue normal diet unless advised otherwise by the physician.
Treatment Duration
- Usual course of treatment is 7 days, may be continued for up to 14 days if required.
Absorption
- About 40% to 50% whether administered with or without food.
Overgrowth of Clostridia
- Possible consequence of normal flora alteration due to broad spectrum antibiotics usage.
Gastric Lavage
- May be indicated in case of overdose.
No Antidote
- Specific antidote for overdose does not exist.
Renal Impairment Dosage
- Normal dose and schedule may be given in patients with creatinine clearances of 20 ml/min or greater, different recommendation for patients with creatinine clearances less than 20 ml/min.
Immature Infant Usage
- Safety and efficacy not established in children aged less than 6 months.
Normal Flora Alteration
- Alters the normal flora of the colon, may permit overgrowth of Clostridia.
Animal Reproduction Studies
- Not always predictive of human response.
Excretion in Human Milk
- Not known if cefixime is excreted in human milk, caution when administered to a nursing woman.
Cefixime Characteristics
- Highly stable in the presence of beta-lactamase enzyme, may be susceptible to organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases.
Effective Against
- Streptococcus pneumonia, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae, Moraxella catarrhalis, and Enterobacter species.
Possible Adverse Reactions
- Allergies in the form of rash, pruritus, urticaria, drug fever, and arthralgia, thrombocytopenia, leukopenia, eosinophilia, mild transient change in liver and renal function tests, genital pruritus, vaginitis.
Antibiotic Class
- Third generation semisynthetic cephalosporin antibiotic for oral administration.
Bacterial Cell Wall Interference
- Kills bacteria by interfering in the synthesis of bacterial cell wall.
High Stability
- Cefixime is highly stable in the presence of beta-lactamase enzymes.
Absorption with Food
- Not significantly modified by the presence of food.
Absorption without Food
- Not significantly modified by the absence of food.
Prothrombin Time Effects
- Increases in prothrombin times have been noted in a few patients.
Anticoagulant Therapy
- Care should be taken in patients receiving anticoagulant therapy.
Antibiotic Usage in Pregnancy
- Use during pregnancy only if clearly needed.
Infections Treatment
- Used for the treatment of urinary tract infections, tonsillitis, pharyngitis, bronchitis, fungal, and gonococcal infections.
Storage and Disposal
- Proper storage and disposal of the expired and unused medications are important to avoid health problems.
Antibiotic Class and Penicillin
- Partial cross-allergenicity between penicillins and cephalosporins, patients have had severe reactions (including anaphylaxis) to both classes of drugs.
Diarrhea Treatment
- Diarrhea may occur as a side effect but should stop when the course is complete.
Alcohol Interaction
- Avoid consuming alcohol while taking Saver 400 mg Capsule as it may cause increased side effects.
Rash Treatment
- If a rash occurs, discontinue the drug and inform the healthcare professional.