Saver 400 mg (Capsule)

Title

• Saver 400 mg Capsule

Categories

• Antibiotic
• Medication

Description

• An orally active cephalosporin antibiotic with bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms.

Dosage

• The usual course of treatment is 7 days, may be continued for up to 14 days if required.

Mode of Action

• Bactericidal against a broad spectrum of gram-positive and gram-negative bacteria by interfering in the synthesis of bacterial cell wall.

Indications

• Treatment of upper respiratory tract infections (URTI), lower respiratory tract infections, urinary tract infections caused by susceptible microorganisms.

Contraindications

• Known hypersensitivity to cephalosporin antibiotics.

Storage Conditions

• Keep below 30°C temperature, protected from light & moisture, out of the reach of children.

Therapeutic Class

• Third generation Cephalosporins

Pregnancy & Lactation

• Use during pregnancy only if clearly needed, caution when administered to a nursing woman.

Precautions & Warnings

• Given with caution to patients who have shown hypersensitivity to other drugs, administered with caution in patients with markedly impaired renal function.

Interaction

• Increases in prothrombin times noted, care should be taken in patients receiving anticoagulant therapy.

Side Effects

• Gastrointestinal disturbances, central nervous system effects, hypersensitivity reactions, hematological and clinical chemistry changes.

Overdose Effects

• Gastric lavage may be indicated, no specific antidote exists, not removed in significant quantities by hemodialysis or peritoneal dialysis.

Compound Summary

• Molecular Formula: C16H15N5O7S2, Chemical Structure available

Commonly Asked Questions

• About uses, side effects, storage, treatment of cold and flu, special dietary instructions, use in infants, classification, interactions, usage with acetaminophen, time to work, when to inform a doctor, and quick tips.

Hypersensitivity Reactions

• Rash, pruritus, urticaria, drug fever, arthralgia.

Usual Adult Dosage

• 200-400 mg daily according to the severity of the infection, given either as a single dose or in two divided doses.

Elderly Dosage

• Same dose as recommended for adults, renal function assessment and dosage adjustment in severe renal impairment.

Children's Dosage

• 8 mg/kg/day administered as a single dose or in two divided doses, specific daily doses suggested based on age and weight.

Dosage in Renal Impairment

• Administered in the presence of impaired renal function, dose and schedule adjustment based on creatinine clearance.

Digestive System Effects

• Diarrhea, stool changes, nausea, abdominal pain, dyspepsia, vomiting, flatulence, and pseudomembranous colitis.

Neurological Effects

• Headache and dizziness.

Hematological and Clinical Chemistry Effects

• Thrombocytopenia, leukopenia, eosinophilia, mild transient change in liver and renal function tests.

Miscellaneous Effects

• Genital pruritus, vaginitis.

Effects on Breastfeeding

• Cautious usage during nursing.

Dietary Instructions

• Continue normal diet unless advised otherwise by the physician.

Treatment Duration

• Usual course of treatment is 7 days, may be continued for up to 14 days if required.

Absorption

• About 40% to 50% whether administered with or without food.

Overgrowth of Clostridia

• Possible consequence of normal flora alteration due to broad spectrum antibiotics usage.

Gastric Lavage

• May be indicated in case of overdose.

No Antidote

• Specific antidote for overdose does not exist.

Renal Impairment Dosage

• Normal dose and schedule may be given in patients with creatinine clearances of 20 ml/min or greater, different recommendation for patients with creatinine clearances less than 20 ml/min.

Immature Infant Usage

• Safety and efficacy not established in children aged less than 6 months.

Normal Flora Alteration

• Alters the normal flora of the colon, may permit overgrowth of Clostridia.

Animal Reproduction Studies

• Not always predictive of human response.

Excretion in Human Milk

• Not known if cefixime is excreted in human milk, caution when administered to a nursing woman.

Cefixime Characteristics

• Highly stable in the presence of beta-lactamase enzyme, may be susceptible to organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases.

Effective Against

• Streptococcus pneumonia, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae, Moraxella catarrhalis, and Enterobacter species.

Possible Adverse Reactions

• Allergies in the form of rash, pruritus, urticaria, drug fever, and arthralgia, thrombocytopenia, leukopenia, eosinophilia, mild transient change in liver and renal function tests, genital pruritus, vaginitis.

Antibiotic Class

• Third generation semisynthetic cephalosporin antibiotic for oral administration.

Bacterial Cell Wall Interference

• Kills bacteria by interfering in the synthesis of bacterial cell wall.

High Stability

• Cefixime is highly stable in the presence of beta-lactamase enzymes.

Absorption with Food

• Not significantly modified by the presence of food.

Absorption without Food

• Not significantly modified by the absence of food.

Prothrombin Time Effects

• Increases in prothrombin times have been noted in a few patients.

Anticoagulant Therapy

• Care should be taken in patients receiving anticoagulant therapy.

Antibiotic Usage in Pregnancy

• Use during pregnancy only if clearly needed.

Infections Treatment

• Used for the treatment of urinary tract infections, tonsillitis, pharyngitis, bronchitis, fungal, and gonococcal infections.

Storage and Disposal

• Proper storage and disposal of the expired and unused medications are important to avoid health problems.

Antibiotic Class and Penicillin

• Partial cross-allergenicity between penicillins and cephalosporins, patients have had severe reactions (including anaphylaxis) to both classes of drugs.

Diarrhea Treatment

• Diarrhea may occur as a side effect but should stop when the course is complete.

Alcohol Interaction

• Avoid consuming alcohol while taking Saver 400 mg Capsule as it may cause increased side effects.

Rash Treatment

• If a rash occurs, discontinue the drug and inform the healthcare professional.

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