Tensnil 10 mg (Tablet)
Unit Price: ৳ 4.01 (10 x 10: ৳ 401.00)
Strip Price: ৳ 40.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobazam |
| Company | Alco pharma ltd |
Indications
- Acute anxiety relief
- Chronic anxiety relief
- Restlessness relief
- Excitement relief
- Sleep disturbances relief
- Psychovegetative disorders relief
- Psychosomatic disorders relief
- Depression treatment
- Adjunctive therapy for epilepsy
- Schizophrenia adjunctive therapy
Pharmacology
- Binds to chloride ionopore
- Increases GABA receptor duration
- Enhances post-synaptic inhibitory effect
Dosage
- Customizable dosage
- Dosage adjustment based on individual response
- Recommended maximum daily dose
- Different dosages for adults, elderly, and children
- Dosage adjustment after symptom improvement
- Recommendation for timing of doses
- Shortest possible treatment duration
- Gradual discontinuation of treatment
Administration
- Can be administered whole or crushed
- Can be mixed in applesauce
- Can be taken with or without food
- Option to divide tablets for lower doses
Interaction
- Increased bioavailability with alcohol consumption
- Mutually potentiating effect with CNS depressant drugs
- Enhanced risk with concomitant use of opioids
- Dosage adjustment with anticonvulsants co-administration
- Possible enhancement of narcotic analgesics effects
- Enhanced effects with muscle relaxants
- Increased exposure with CYP2C19 inhibitors
- Necessity of dose adjustment for CYP2D6 substrates
Contraindications
- Hypersensitivity to clobazam or its excipients
- Myasthenia gravis
- Severe respiratory insufficiency
- Sleep apnoea syndrome
- Severe impairment of liver function
- Breastfeeding
Side Effects
- Decreased appetite
- Irritability
- Aggression
- Restlessness
- Depression
- Somnolence
- Sedation
- Dizziness
- Disturbance in attention
- Headache
- Tremor
- Dry mouth
- Nausea
- Constipation
- Rash
- Muscle spasms
- Muscle weakness
- Fatigue
- Weight fluctuation
Pregnancy & Lactation
- Not recommended in first trimester
- Potential risk to fetus
- Crosses the placenta
- Potential for neonatal respiratory depression
- Developed physical dependence in newborns
- Not to be used during breastfeeding
Precautions & Warnings
- Risk of serious skin reactions
- Potential for respiratory depression
- Potential for muscle weakness
- Increased susceptibility in renal and hepatic impairment
- Increased risk of adverse reactions in the elderly
- Potential for decreased anticonvulsant efficacy
- Increased levels in CYP2C19 poor metabolizers
- Potential for increased suicidality
- Risk with concomitant use of CYP2C19 inhibitors
Therapeutic Class
- Benzodiazepine hypnotics
Storage Conditions
- Do not use past expiry date
- Store below 30°C
- Protect from light
- Keep out of reach of children