Clintrix 1.2%+0.025% (Topical Gel)

Indications

• Topical treatment of Acne vulgaris

Pharmacology

• Combination of lincosamide antibiotic (Clindamycin phosphate) and retinoid (Tretinoin)
• Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents elongation of peptide chain
• Tretinoin decreases the cohesiveness of follicular epithelial cells and increases the turnover of cells
• Clindamycin inhibits the activity of Propionibacterium acne

Dosage & Administration

• Application before sleep with gentle face wash
• Apply sunscreen in the morning after application
• Avoid washing face more than 2-3 times a day
• Safety and effectiveness not established in children below 12 years

Interaction

• Caution with concomitant use of potentially irritating topical products
• Avoid concomitant use with Erythromycin
• Careful use with neuromuscular medicine

Contraindications

• Hypersensitivity to Clindamycin or Tretinoin or any other component of the gel

Side Effects

• Erythema
• Scaling
• Nasopharyngitis
• Dry skin
• Cough
• Sinusitis
• Diarrhea

Pregnancy & Lactation

• Not known whether Clindamycin or Tretinoin is excreted in human milk
• Exercise special caution while applying to a nursing mother

Precautions & Warnings

• Avoid application to eyes, nose, ear, lips, cuts, burns, and other infections
• Keep away from sunlight after application

Therapeutic Class

• Topical antibiotic & retinoid preparations

Storage Conditions

• Keep below 25°C temperature
• Away from light & moisture
• Keep out of the reach of children

Related Brands

• Daclin T 1.2%+0.025% (Topical Gel) - aci-limited
• Dalatic Plus 1.2%+0.025% (Topical Gel) - drug-international-ltd