Dilocard 12.5 mg (Tablet)

Unit Price: ৳ 5.00 (30's pack: ৳ 150.00)

Medicine Details

Category Details
Generic Carvedilol
Company The white horse pharmaceuticals ltd
Also available as
Dilocard 625 mg tablet

Title

  • Dilocard

Categories

  • Medicine
  • Pharmaceutical

Description

  • Dilocard is indicated for the treatment of mild, moderate, or severe heart failure of ischemic or cardiomyopathic origin, in conjunction with digitalis, diuretics, and ACE inhibitor, to reduce the progression of disease as evidenced by cardiovascular death, cardiovascular hospitalization, or the need to adjust other heart failure medications. Dilocard may be used in patients unable to tolerate an ACE inhibitor. Dilocard may be used in patients who are not receiving digitalis, hydralazine, or nitrate therapy.
  • Carvedilol is a cardiovascular drug whose main pharmacological action is non-selective antagonism of β-adrenergic receptors but which also possesses appreciable a-adrenergic antagonistic activity. It also has antiproliferative properties and is a scavenger of reactive free oxidant radicals. It is used in the treatment of hypertension, angina pectoris, and congestive heart failure.
  • In hypertension: initially, 12.5 mg once daily, increased after 2 days to the usual dose of 25 mg once daily; if necessary the dose may be further increased at intervals of at least 2 weeks to the maximum 50 mg daily in single or divided doses. In elderly patients, the initial dose of 12.5 mg daily may provide satisfactory control.
  • In angina pectoris: the recommended dose for initiation of therapy is 12.5 mg twice daily for the first 2 days. Thereafter, the recommended dosage is 25 mg twice daily. For elderly patients, the maximum daily dose is 50 mg daily in divided doses.
  • In heart failure: initially, 3.125 mg twice daily (with food) may be given, the dose may be increased at intervals of at least 2 weeks to 6.25 mg twice daily, then to 12.5 mg twice daily, then to 25 mg twice daily. The dose may be increased to the highest dose tolerated, maximum 25 mg twice daily in patients less than 85 kg body-weight and 50 mg twice daily in patients over 85 kg.
  • Digoxin: In normal healthy volunteers a single dose of Dilocard taken together with a single dose of digoxin resulted in significantly increased levels of digoxin 24 hours later.
  • Pregnancy & Lactation: Carvedilol should not be used during breastfeeding, since no studies have been performed in lactating women, and animal studies have shown that carvedilol is excreted in breast milk.

Indications

  • Treatment of mild, moderate or severe heart failure of ischemic or cardiomyopathic origin
  • Used in conjunction with digitalis, diuretics, and ACE inhibitor
  • Reduces the progression of disease as evidenced by cardiovascular death, cardiovascular hospitalization, or the need to adjust other heart failure medications
  • May be used in patients unable to tolerate an ACE inhibitor
  • May be used in patients not receiving digitalis, hydralazine, or nitrate therapy

Pharmacology

  • Non-selective antagonism of β-adrenergic receptors
  • Appreciable a-adrenergic antagonistic activity
  • Antiproliferative properties
  • Scavenger of reactive free oxidant radicals
  • Used in the treatment of hypertension, angina pectoris, and congestive heart failure

Dosage & Administration

  • Initial dose in hypertension: 12.5 mg once daily
  • Usual dose in hypertension: 25 mg once daily
  • Maximum dose in hypertension: 50 mg daily in single or divided doses
  • Initial dose in angina pectoris: 12.5 mg twice daily for the first 2 days
  • Recommended dosage in angina pectoris: 25 mg twice daily
  • Maximum daily dose in angina pectoris: 50 mg daily in divided doses
  • Initial dose in heart failure: 3.125 mg twice daily (with food)
  • Maximum dose in heart failure: 25 mg twice daily in patients less than 85 kg body-weight and 50 mg twice daily in patients over 85 kg

Interaction

  • Increased levels of digoxin when taken together with Dilocard
  • Rifampin results in a 60% decrease in Cmax and AUC
  • Dilocard does not alter the in vitro plasma protein binding of warfarin
  • Potentiates the pressor reaction which may follow the sudden withdrawal of treatment with clonidine

Contraindications

  • Decompensated heart failure requiring intravenous inotropic therapy
  • Bronchial asthma or related bronchospastic conditions
  • Second or third-degree AV block
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Cardiogenic shock or severe bradycardia

Side Effects

  • Postural hypotension
  • Dizziness
  • Headache
  • Fatigue
  • GI disturbances
  • Bradycardia
  • Peripheral oedema
  • Painful extremities
  • Dry mouth
  • Dry eyes
  • Impotence
  • Disturbances of micturition
  • Influenza-like symptoms
  • Angina
  • AV block
  • Exacerbation of intermittent claudication or Raynaud's phenomenon
  • Allergic skin reactions
  • Exacerbation of psoriasis
  • Nasal stuffiness
  • Wheezing
  • Depressed mood
  • Sleep disturbances
  • Paresthesia
  • Changes in liver enzymes
  • Thrombocytopenia
  • Leukopenia

Pregnancy & Lactation

  • Should not be used during breastfeeding
  • No studies performed in lactating women
  • Animal studies show excretion in breast milk
  • No information available on safety and efficacy of use in neonates

Precautions & Warnings

  • Take caution in hepatic impairment
  • Monitor clinical status in heart failure for 2-3 hours after initiation and after increasing each dose
  • Ensure renal function and heart failure are not deteriorating before increasing dose

Therapeutic Class

  • Alpha adrenoceptor blocking drugs
  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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