Flusaf 150 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | The white horse pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is an essential component of the fungal cell membrane responsible for the synthesis of ergosterol.
Dosage & Administration
- Adults:
- Various dosage regimens for different conditions
- Child over 1 year:
- Specific dosage regimens
- Use in Specific Population:
- Dosage adjustments for elderly and patients with renal impairment
Interaction
- Interactions with warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, food, cemetidine, antacids, total body irradiation, theophylline, and other medications
- Recommendations for co-administration
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds.
Side Effects
Common side effects include symptoms associated with the gastrointestinal tract such as nausea, abdominal discomfort, diarrhea, and flatulence. Rare adverse events such as rash and anaphylaxis have been reported.
Pregnancy & Lactation
Fluconazole should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed. Its use in nursing mothers is not recommended.
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological and other biochemical function tests in some patients
- Rare occurrences of hepatic necrosis, exfoliative cutaneous reactions, and severe cutaneous reactions
- Recommendations for rash development and close monitoring in certain patient groups
- Use during lactation not recommended
- Unlikely to impair a patient's ability to drive or use machinery
Use in Special Populations
- Use in the elderly: Normal dose should be used if there is no evidence of renal impairment. Dosage adjustments for patients with renal impairment
- Use in renal impairment: Dosage adjustments based on creatinine clearance
Overdose Effects
Supportive measures and symptomatic treatment recommended in the event of overdosage. Forced volume diuresis and haemodialysis may aid elimination.
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.