Metfar SR 500 mg (Tablet (Sustained Release))
Unit Price: ৳ 6.00 (30's pack: ৳ 180.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | The white horse pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children aged 10 years and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Usual starting dose for adults: 500 mg twice a day or 850 mg once a day
- Usual starting dose for children: 500 mg twice a day
- Renal impaired patient precautions
Interaction
- No information available about the interaction with Furosemide when co-administered chronically
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- Effects on Nifedipine and Cimetidine pharmacokinetics
- Certain drugs that may produce hyperglycemia and lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure (GFR <30 mL/min)
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin instead of metformin during pregnancy
- Excretion into human breast milk
- Recommendation to discontinue breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin or insulin secretagogue
- Regular monitoring of renal function
- Precaution in conditions causing dehydration or serious infections
- Necessity of annual Vitamin B-12 levels estimation
- Interaction with sulphonylurea, anticoagulants, and cimetidine
- Stabilization of diabetic patients with metformin and insulin in hospital
Use in Special Populations
- Adjustment of metformin dosage based on renal function in the elderly
- Caution in prescribing to children aged between 10 and 12 years
- Regular renal function assessment
- Caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen with Metformin doses up to 85 gm
- Occurrence of lactic acidosis in overdose circumstances
- Treatment of lactic acidosis in hospital
- Hemodialysis as the most effective method to remove lactate and Metformin
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children