Metfar SR 1000 mg (Tablet (Sustained Release))
Unit Price: ৳ 9.00 (30's pack: ৳ 270.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | The white horse pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- First-line therapy after diet failure
- Management of overweight patients
- Monotherapy for adults
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Starting dose of 500 mg or 850 mg
- Maximum daily dose of 2000 mg
- Renal impaired patient precautions
- Immediate release and extended release tablet options
Interaction
- Potential interaction with Furosemide and Nifedipine
- Competition with cationic drugs for renal tubular transport systems
- Effects on drugs causing hyperglycemia or hypoglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Vitamin B12 absorption decrease
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Excretion into breast milk
- Recommendation against breastfeeding during treatment
Precautions & Warnings
- Excretion by the kidney
- Risk of vitamin B12 level lowering
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Discontinuation before surgery and certain clinical investigations
- Annual estimation of Vitamin B-12 levels
- Stabilization with insulin in hospital
- Possible interaction with anticoagulants
Use in Special Populations
- Renal function assessment in elderly subjects
- Diagnosis confirmation before treatment in pediatric population
- Caution in prepubescent children
- Regular renal function assessment
- Contraindicated in patients with GFR < 30 ml/min
Overdose Effects
- Lactic acidosis as a medical emergency
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children