Sigtil 100 mg (Tablet)
Unit Price: ৳ 28.00 (10's pack: ৳ 280.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin |
| Company | The white horse pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus
- Not for use in patients with type 1 diabetes
- Not for the treatment of diabetic ketoacidosis
Pharmacology
- Sitagliptin is a DPP-4 inhibitor
- Slows inactivation of incretin hormones
- Increases and prolongs action of active intact hormones
- Increases insulin release and decreases glucagon levels in a glucose-dependent manner
Dosage & Administration
- Recommended dose: 50 mg twice a day or 100 mg once daily
- Can be taken with or without food
Interaction
- Does not meaningfully alter the pharmacokinetics of several drugs
- Slightly increases mean Digoxin concentration
Contraindications
- History of serious hypersensitivity reaction to sitagliptin
Side Effects
- Common adverse reactions include headache, upper respiratory tract infection, and nasopharyngitis
- Hypoglycemia may occur in patients treated with the combination of Sigtil and sulfonylurea and add on to insulin
Pregnancy & Lactation
- Pregnancy Category B
- Should be used during pregnancy only if clearly needed
- Caution advised when administered to a nursing woman
Precautions & Warnings
- Prompt discontinuation if pancreatitis is suspected
- Dosage adjustment recommended in patients with renal insufficiency
- Careful dose selection in elderly patients
Use in Special Populations
- Safety and effectiveness in pediatric patients under 18 years of age not established
- Careful dose adjustment for patients with renal insufficiency
Overdose Effects
- Maximal mean increases in QTc observed at high doses
- Supportive measures recommended in the event of overdose
Therapeutic Class
- Dipeptidyl Peptidase-4 (DPP-4) inhibitor
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep out of reach of children
- Do not use later than the date of expiry
- To be dispensed only on the prescription of a registered physician