Sigtil M 50 mg+1000 mg (Tablet)

Unit Price: ৳ 22.00 (10's pack: ৳ 220.00)

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company The white horse pharmaceuticals ltd
Also available as
Sigtil m 50 mg tablet

Indications

  • Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
  • Not indicated for type 1 diabetes or diabetic ketoacidosis
  • Not studied in patients with a history of pancreatitis

Pharmacology

  • Combines sitagliptin and metformin to improve glycemic control in type 2 diabetes
  • Mechanism of action of sitagliptin as a DPP-4 inhibitor
  • Mechanism of action of metformin as a biguanide class agent
  • Involvement of incretin hormones in glucose homeostasis

Dosage & Administration

  • Individualized dosing based on patient's current regimen, effectiveness, and tolerability
  • Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Twice daily administration with meals

Interaction

  • Cationic drugs elimination caution
  • Metformin may decrease the anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction

Side Effects

  • Common adverse reactions such as diarrhea, upper respiratory tract infection, and headache
  • Hypoglycemia as an adverse reaction with certain combinations
  • Nasopharyngitis reported in patients on sitagliptin monotherapy

Pregnancy & Lactation

  • Safety in pregnant women not well-known
  • Caution advised for nursing women

Precautions & Warnings

  • Risk of lactic acidosis with metformin accumulation
  • Regular monitoring of thyroid-stimulating hormone levels recommended
  • Caution advised in patients with hepatic disease
  • Assessment of renal function before and during treatment
  • Prompt discontinuation if suspected pancreatitis

Overdose Effects

  • Supportive measures for sitagliptin overdose
  • Possibility of metformin overdose and its clearance with dialysis

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Use before the expiry date

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