Spinolex 10 mg (Tablet)
Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | The white horse pharmaceuticals ltd |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain
- clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
- inhibits monosynaptic and polysynaptic reflexes
- stimulates GABA receptors
- inhibits release of glutamate and aspartate
- produces CNS depression
- exerts antinociceptive effect
Dosage & Administration
- 5 mg 3 times daily for adults & children over 10 years
- gradually increased dosage
- max. 100 mg daily
- dosage varies for children under 10 years based on age
Interaction
- Increased sedation with central nervous system agents
- increased risk of respiratory depression
- interaction with antihypertensives
- potentiation of effects with tricyclic antidepressants
- reports of mental confusion with levodopa and carbidopa
- interaction with MAO inhibitors and magnesium sulphate
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- transient drowsiness
- daytime sedation
- dizziness
- weakness
- fatigue
- headache
- insomnia
- euphoria
- confusion
- hallucinations
- respiratory depression
- hypotension
- nausea
- constipation
- urinary frequency
- rash
- pruritus
- weight gain
- visual disturbances
Pregnancy & Lactation
- Pregnancy category B3
- safe use during pregnancy not established
- crosses placental barrier
- excreted in breast milk in small quantities
Precautions & Warnings
- lower doses for impaired renal function
- caution with psychotic disorders
- monitor for exacerbations of psychiatric disorders
- use with caution in patients with epilepsy
- monitor respiratory and cardiovascular function
- potential improvement in neurogenic disturbances affecting bladder emptying
- poor tolerance in stroke patients
Overdose Effects
- importance of gastric lavage in severe overdose
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Keep below 30°C temperature
- away from light & moisture
- keep out of the reach of children