Wincef 500 mg (Capsule)

Unit Price: ৳ 12.50 (24's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Cephradine
Company The white horse pharmaceuticals ltd
Also available as
Wincef 125 mg suspension

Title and Categories

  • Wincef Antibiotic
  • Cephradine
  • First generation Cephalosporins

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Susceptible microorganisms (e.g. Staphylococci, Streptococci, E. coli)

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in cell wall of bacteria

Dosage and Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosage adjustments for elderly and patients with impaired renal or hepatic function

Interaction

  • Risk of kidney damage when used with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood disorders
  • Fever
  • Confusion
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy and Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers
  • May cause dizziness

Precautions and Warnings

  • Risk of superinfection with prolonged use
  • Careful administration to patients hypersensitive to penicillins
  • Cephalosporins may cause positive result in Coombs' testing
  • Potential for false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose, caution in patients with specific hereditary problems

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Dose recommendations for patients on haemodialysis
  • Higher doses may be required for severe infections

Overdose Effects

  • Non-specific symptoms (e.g. nausea, vomiting, diarrhea)
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Storage duration for reconstituted suspension
  • Storage duration for injection solutions
  • Potency retention at different storage conditions

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