Yogra 50 mg (Tablet)
Unit Price: ৳ 30.00 (10's pack: ৳ 300.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | The white horse pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of men with erectile dysfunction
- Treatment of pulmonary arterial hypertension
- Requirement for sexual stimulation for effectiveness
Description
Pharmacology
- Mechanism of Action: Inhibition of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Pharmacokinetics and Metabolism:
- Mean absolute bioavailability of 41%
- Elimination predominantly by hepatic metabolism
- Converted to an active metabolite with properties similar to the parent
- Terminal half lives of about 4 hours
- Absorption and Distribution:
- Rapid absorption
- Maximum observed plasma concentrations reached within 30 to 120 minutes
- Metabolism and Excretion:
- Cleared by hepatic microsomal isoenzymes
- Excreted as metabolites predominantly in the feces
- Pharmacokinetics in Special Populations: Reduced clearance in healthy elderly volunteers
Dosage & Administration
- Recommended dose for erectile dysfunction: 50 mg
- Recommended dose for pulmonary arterial hypertension: 20 mg three times a day
- Dosing frequency: once per day
Interaction
- Metabolism primarily mediated by cytochrome P450 (CYP) isoforms 3A4 and 2C9
- Inhibitors of these isoenzymes may reduce clearance
- Inducers of these isoenzymes may increase clearance
- Enhanced plasma levels with inhibitors such as cimetidine, erythromycin, saquinavir, ketoconazole, itraconazole, ritonavir, and bosentan
Contraindications
- Hypersensitivity to any component
- Concomitant use with organic nitrates
Side Effects
- Body as a whole
- Cardiovascular
- Digestive
- Hemic and Lymphatic
- Metabolic and Nutritional
- Musculoskeletal
- Nervous
- Respiratory
- Skin and Appendages
- Special Senses
- Urogenital
- Serious cardiovascular, cerebrovascular, and vascular events
- Seizure, anxiety, and transient global amnesia
- Prolonged erection, priapism, and hematuria
Pregnancy & Lactation
Pregnancy category B
Precautions & Warnings
- Caution with co-administration of alpha-blockers
- Consideration for patients with underlying conditions such as anatomical deformation of the penis, bleeding disorders, active peptic ulceration
- Potential cardiac risk of sexual activity in patients with preexisting cardiovascular disease
Overdose Effects
Adverse events similar to lower doses, increased incidence rates and severities
Therapeutic Class
Drugs for Erectile Dysfunction
Storage Conditions
Keep in a dry place, away from light and heat, out of the reach of children