Yogra 100 mg (Tablet)

Unit Price: ৳ 50.00 (10's pack: ৳ 500.00)

Medicine Details

Category Details
Generic Sildenafil citrate
Company The white horse pharmaceuticals ltd
Also available as
Yogra 50 mg tablet

Title

  • Yogra

Categories

  • Medicine
  • Pharmaceutical

Description

  • A medicine used for the treatment of erectile dysfunction and pulmonary arterial hypertension

Dosage instructions

  • Recommended dose for erectile dysfunction: 50 mg taken 1 hour before sexual activity, with the possibility of adjustment to a maximum of 100 mg or a minimum of 25 mg. Maximum dosing frequency is once per day.

Active ingredient

  • Sildenafil

Pharmacological action

  • Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)

Mode of action

  • Facilitates smooth muscle relaxation and increased blood flow to the penile tissues when activated by nitric oxide released during sexual stimulation

Contraindications

  • Hypersensitivity to any component of the medication
  • Concomitant use with organic nitrates

Interactions

  • Metabolism is mediated by cytochrome P450 isoforms 3A4 and 2C9. Inhibitors of these isoenzymes can increase Yogra clearance, while inducers may decrease Yogra clearance

Precautions warnings

  • Caution when co-administered with alpha-blockers due to potential additive effect on blood pressure
  • Consideration should be given to patients with underlying cardiovascular conditions, bleeding disorders, or active peptic ulceration

Pregnancy lactation

  • Pregnancy category B; not indicated for use by women
  • No evidence of teratogenicity or embryotoxicity in animal studies

Side effects

  • Various side effects across different body systems, including cardiovascular, digestive, nervous, respiratory, skin, and urogenital systems

Overdose effects

  • Adverse events at higher incidence rates and severity with doses exceeding 800 mg
  • Standard supportive measures should be adopted in cases of overdose

Drug class

  • Drugs for Erectile Dysfunction

Storage conditions

  • Keep in a dry place, away from light and heat. Keep out of the reach of children

Indications

  • Treatment of men with erectile dysfunction and pulmonary arterial hypertension

Therapeutic population

  • Men with erectile dysfunction or pulmonary arterial hypertension

Metabolism

  • Predominantly hepatic metabolism, mainly via cytochrome P450 3A4

Absorption

  • Rapidly absorbed after oral administration, with maximum plasma concentrations reached within 30 to 120 minutes in the fasted state

Distribution

  • Metabolites excreted predominantly in the feces and to a lesser extent in the urine

Pharmacokinetics special populations

  • Reduced clearance and higher plasma AUC values in healthy elderly volunteers (65 years or over)

Plasma levels

  • Factors associated with increased plasma levels include age >65, hepatic impairment, severe renal impairment, and concomitant use of potent cytochrome P450 3A4 inhibitors

Absorption variability

  • Rate of absorption reduced when taken with a high fat meal

Pharmacokinetics interaction

  • Strong CYP3A4 inhibitors are expected to have greater effects on Yogra clearance
  • No effect on pharmacokinetics of certain inhibitors or diuretics

Clinical data

  • No controlled clinical data on the safety or efficacy in patients with certain cardiovascular conditions or genetic disorders
  • Potential cardiac risk of sexual activity in patients with preexisting cardiovascular disease

Sensitive groups

  • Patients with left ventricular outflow obstruction, severely impaired autonomic control of blood pressure, and certain underlying conditions

Adverse events post marketing

  • Reports of cardiovascular, cerebrovascular, and vascular events post-marketing
  • Prolonged erection and priapism reported infrequently since market approval

Treatments combinations

  • Safety and efficacy of combinations with other treatments for erectile dysfunction not studied

Potential complications

  • Potential complications in patients with bleeding disorders and active peptic ulceration
  • Potential effects in patients with anatomical deformation of the penis or conditions predisposing them to priapism

Adverse effects high doses

  • Visual disturbances, decreased blood pressure, syncope, and prolonged erection at high doses

Overdose treatment

  • Standard supportive measures, with renal dialysis not expected to accelerate clearance

Blood pressure effects

  • Systemic vasodilatory properties, which may augment the blood pressure-lowering effect of other anti-hypertensive medications

Cardiac risk sexual activity

  • Potential cardiac risk in patients with preexisting cardiovascular disease
  • Transient decreases in supine blood pressure reported in healthy volunteers

Patient groups studies

  • No controlled clinical data on safety or efficacy in certain patient groups

Erection duration

  • Reports of prolonged erection and priapism

Ritonavir interaction

  • Caution recommended when prescribed to patients taking ritonavir

Visual disturbances

  • Visual disturbances more common at higher levels of Yogra exposure

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